Dissecting Rapamycin sensitive and insensitive effects of mTOR

剖析 mTOR 的雷帕霉素敏感和不敏感效应

• 批准号: nhmrc : 1120201
• 负责人: Dr Jacqueline Stoeckli
• 金额: $ 80.85万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-rapamycin-sensitive-effects-mtor/946450
• 关键词: Dissecting; Rapamycin; sensitive; insensitive; effects

All cells possess machinery that can sense nutrient availability and trigger cell growth and nutrient storage pathways. However, nutrient oversupply is detrimental to health. Recently, it was shown that drugs that inhibit the nutrient sensors have life extending effects. Our laboratory has discovered a novel mechanism by which these drugs might be mediating these beneficial effects that could change the way we think about the beneficial effects of these drugs and their mode of action

所有细胞都拥有能够感知营养供应并触发细胞生长和营养储存途径的机械。然而，营养过剩对健康是有害的。最近有研究表明，抑制营养感受器的药物具有延年益寿的作用。我们的实验室发现了一种新的机制，这些药物可能通过这种机制来调节这些有益的效果，这可能会改变我们对这些药物的有益效果及其作用模式的看法。