Dissecting the role of insulin-regulated phosphorylation of Rab guanine nucleotide exchange factors in GLUT4 trafficking

剖析胰岛素调节的 Rab 鸟嘌呤核苷酸交换因子磷酸化在 GLUT4 运输中的作用

• 批准号: nhmrc : 1047067
• 负责人: Dr Jacqueline Stoeckli
• 金额: $ 41.91万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-role-insulin-glut4-trafficking/111905
• 关键词: Dissecting; role; insulin; regulated; phosphorylation

Diabetes and obesity are epidemic in the developed world. Impaired insulin action is a major cause. A key contributor is reduced glucose uptake into muscle and fat driving the pancreas to overproduce insulin. We have recently discovered three new molecules that we believe hold the secret to how insulin regulates the removal of the glucose from the blood stream after a meal. This proposal focuses on these three molecules and their regulation.

糖尿病和肥胖症在发达国家很流行。胰岛素作用受损是一个主要原因。一个关键因素是减少葡萄糖摄取到肌肉和脂肪驱动胰腺过量生产胰岛素。我们最近发现了三种新的分子，我们相信它们掌握着胰岛素如何调节餐后葡萄糖从血流中清除的秘密。该提案重点关注这三种分子及其调控。