The role of Rab GTPases and Rab GTPase activating proteins in Insulin Action

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Type 2 diabetes is one of the most rapidly growing diseases in the world. While lifestyle factors have contributed to this we must understand how insulin works under normal circumstances to aid in the fight against this disease. Our goal is to provide the molecular blueprint for one of insulin's major metabolic actions that is disrupted in diabetes - glucose transport into muscle and fat cells. Over the past few years we have begun to fill in the missing pieces to this puzzle.