The role of Rab GTPases and Rab GTPase activating proteins in Insulin Action

Rab GTPase 和 Rab GTPase 激活蛋白在胰岛素作用中的作用

• 批准号: nhmrc : 535923
• 负责人: Dr Jacqueline Stoeckli
• 金额: $ 50.79万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-rab-gtpases-insulin-action/99582
• 关键词: role; Rab; GTPases; GTPase; activating

Type 2 diabetes is one of the most rapidly growing diseases in the world. While lifestyle factors have contributed to this we must understand how insulin works under normal circumstances to aid in the fight against this disease. Our goal is to provide the molecular blueprint for one of insulin's major metabolic actions that is disrupted in diabetes - glucose transport into muscle and fat cells. Over the past few years we have begun to fill in the missing pieces to this puzzle.

2型糖尿病是世界上增长最快的疾病之一。虽然生活方式因素对此有贡献，但我们必须了解胰岛素在正常情况下如何工作，以帮助对抗这种疾病。我们的目标是为胰岛素的主要代谢作用之一提供分子蓝图，该代谢作用在糖尿病中被破坏-葡萄糖转运到肌肉和脂肪细胞中。在过去几年中，我们已开始填补这一难题的缺失部分。