Dissecting the role of the IL-3 receptor alpha subunit and beta-catenin in Acute Myeloid Leukaemia

剖析 IL-3 受体 α 亚基和 β-连环蛋白在急性髓系白血病中的作用

• 批准号: nhmrc : 626947
• 负责人: A/Pr Ian Lewis
• 金额: $ 38.9万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-role-il-myeloid-leukaemia/97571
• 关键词: Dissecting; role; IL; receptor; alpha

Leukaemia is a devastating form of blood cancer affecting both young and old. We aim to understand the mechanisms of uncontrolled cell growth associated with acute myeloid leukaemia. We focus on the role of key growth regulators that are abnormally active in the critical leukaemia stem cells. Understanding the biological and molecular properties of these cells is of considerable importance for development of the next generation of leukaemia therapies.

白血病是一种毁灭性的血癌，影响年轻人和老年人。我们的目的是了解与急性髓系白血病相关的细胞生长不受控制的机制。我们专注于关键的白血病干细胞中异常活跃的关键生长调节因子的作用。了解这些细胞的生物学和分子特性对于开发下一代白血病疗法具有相当重要的意义。