Co-operation between GATA2 mutation or expression and RAS signalling in AML

AML 中 GATA2 突变或表达与 RAS 信号传导之间的合作

• 批准号: nhmrc : 1086302
• 负责人: A/Pr Ian Lewis
• 金额: $ 57.38万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/co-operation-gata2-signalling-aml/519128
• 关键词: Co; operation; between; GATA2; mutation

We have identified a gene GATA2 which, when mutated, can lead to leukaemia (blood cancer). We will collect samples worldwide from families and individuals that carry GATA2 mutations and have developed leukaemia, and will screen for other genetic changes that contribute to leukaemia. We have also identified a novel group of patients who have a low GATA2 activity and who also have mutations in the RAS gene, a known contributor to leukaemia. We will determine how these cooperate to cause leukaemia.

我们已经确定了一个基因GATA 2，当突变时，可以导致白血病（血癌）。我们将在全球范围内收集携带GATA 2突变并患有白血病的家庭和个人的样本，并将筛查导致白血病的其他遗传变化。我们还发现了一组新的患者，他们具有低GATA 2活性，并且还具有RAS基因突变，RAS基因是白血病的已知贡献者。我们将确定它们是如何合作导致白血病的。