FANC gene mutations in Acute Myeloid Leukaemia biology and treatment

FANC 基因突变在急性髓系白血病生物学和治疗中的作用

• 批准号: nhmrc : GNT1145391
• 负责人: A/Pr Ian Lewis
• 金额: $ 90.08万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fanc-gene-mutations-biology-treatment/1348690
• 关键词: FANC; gene; mutations; Acute; Myeloid

We have found mutations in DNA repair genes in AML patients, and associated the presence of these with increased risk of developing AML. Our hypothesis is that the presence of these mutations leads to reduced efficiency of DNA repair, and increased risk of additional mutations and leukaemic transformation. Our aim is therefore to determine the changes associated with these mutations in blood cell precursors, and to investigate the potential of targeted therapies for this group of patients.

我们在AML患者中发现了DNA修复基因的突变，并将这些突变的存在与AML发病风险的增加联系在一起。我们的假设是，这些突变的存在会降低DNA修复的效率，增加额外突变和白血病转化的风险。因此，我们的目标是确定与这些血细胞前体突变相关的变化，并调查针对这类患者的靶向治疗的可能性。