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PHASE I STUDY--LIPOSOME ENCAPSULATED DOXORUBICIN

I 期研究——脂质体封装阿霉素

基本信息

批准号：
6274526
负责人：
David J. Vaughn
金额：
$ 2.5万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-04-15 至 1998-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6274526
关键词：
cardiotoxin clinical research clinical trial phase I dosage forms doxorubicin drug delivery systems human subject human therapy evaluation liposomes neoplasm /cancer chemotherapy pharmacokinetics

项目摘要

The anthracycline, doxorubicin, is active against human lymphomas, leukemias, and solid tumors including breast, lung, stomach and sarcomas. We and others have shown that liposome-encapsulated doxorubicin (LED) retains its antitumor properties and attenuates the dose dependent cardiotoxicity. The objectives of this phase I study are to determine the toxicity of this modified Liposome Encapsulated Doxorubicin (LED) and to assess any antitumor activity of LED.

蒽环类抗生素，阿霉素，对人类淋巴瘤有活性，白血病和实体瘤，包括乳腺癌、肺癌、胃癌和肉瘤我们和其他人已经证明，阿霉素（LED）保留了其抗肿瘤特性，并减弱了剂量依赖性心脏毒性。本I期研究的目的是为了确定这种改良的脂质体包封的毒性，阿霉素（LED），并评估LED的任何抗肿瘤活性。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

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David J. Vaughn其他文献

Microsatellite Instability and Loss of Heterozygosity Have Distinct Prognostic Value for Testicular Germ Cell Tumor Recurrence Somatic Genetic Changes in Association with Testicular Germ Cell Tumor Prognosis Chromosomal Changes in Tgct Microsatellite Instability and Tgct Prognosis

微卫星不稳定性和杂合性丧失对于睾丸生殖细胞肿瘤复发具有独特的预后价值与睾丸生殖细胞肿瘤预后相关的体细胞遗传变化 Tgct 微卫星不稳定性和 Tgct 预后中的染色体变化

DOI：
发表时间：
期刊：
影响因子：
0
作者：
K. Nathanson;David J. Vaughn;Brb;Curie Blvd;Alfredo Velasco;Erick Riquelme;Marcela Schultz;Ivan Wistuba;Luis Villarroel;Moon S. Koh;F. Leach
通讯作者：
F. Leach

Complications associated with chemotherapy in testicular cancer management

睾丸癌治疗中与化疗相关的并发症

DOI：
10.1038/nrurol.2011.26
发表时间：
2011-03-15
期刊：
Nature Reviews Urology
影响因子：
14.600
作者：
Chunkit Fung;David J. Vaughn
通讯作者：
David J. Vaughn

Transrectal Radiofrequency Ablation for Pelvic Recurrence of Bladder Cancer: Case Report and Review of Complications

DOI：
10.1097/01.rvi.0000161145.97509.a1
发表时间：
2005-07-01
期刊：
Short communication
影响因子：
作者：
Craig Campbell;Michael C. Soulen;Stephen C. Horii;Evan S. Seigelman;Stephen E. Rubesin;David J. Vaughn
通讯作者：
David J. Vaughn

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

DOI：
10.1186/s40425-016-0191-4
发表时间：
2016-12-01
期刊：
Journal for ImmunoTherapy of Cancer
影响因子：
10.600
作者：
Sonja Althammer;Keith Steele;Marlon Rebelatto;Tze Heng Tan;Tobias Wiestler;Guenter Schmidt;Brandon Higgs;Xia Li;Li Shi;Xiaoping Jin;Joyce Antal;Ashok Gupta;Koustubh Ranade;Gerd Binning;Joaquim Bellmunt;Ronald de Wit;David J. Vaughn;Yves Fradet;Jae Lyun Lee;Lawrence Fong;Nicholas J. Vogelzang;Miguel A. Climent;Daniel P. Petrylak;Toni K. Choueiri;Andrea Necchi;Winald Gerritsen;Howard Gurney;David I. Quinn;Stéphane Culine;Cora N. Sternberg;Yabing Mai;Markus Puhlmann;Rodolfo F. Perini;Dean F. Bajorin;Padmanee Sharma;Margaret K. Callahan;Emiliano Calvo;Joseph W. Kim;Filipo de Braud;Patrick A. Ott;Petri Bono;Rathi N. Pillai;Michael Morse;Dung T. Le;Matthew Taylor;Pavlina Spilliopoulou;Johanna Bendell;Dirk Jaeger;Emily Chan;Scott J. Antonia;Paolo A. Ascierto;Delphine Hennicken;Marina Tschaika;Alex Azrilevich;Jonathan Rosenberg;Ofer Levy;Christopher Chan;Gady Cojocaru;Spencer Liang;Eran Ophir;Sudipto Ganguly;Amir Toporik;Maya Kotturi;Tal Fridman Kfir;Benjamin M. Murter;Kathryn Logronio;Liat Dassa;Ling Leung;Shirley Greenwald;Meir Azulay;Sandeep Kumar;Zoya Alteber;Xiaoyu Pan;Arthur Machlenkin;Yair Benita;Andrew W. Drake;Ayelet Chajut;Ran Salomon;Ilan Vankin;Einav Safyon;John Hunter;Zurit Levine;Mark White;Rom Leidner;Hyunseok Kang;Robert Haddad;Neil H. Segal;Lori J. Wirth;Robert L. Ferris;F. Stephen Hodi;Rachel E. Sanborn;Thomas F. Gajewski;William Sharfman;Dan McDonald;Shivani Srivastava;Xuemin Gu;Penny Phillips;Chaitali Passey;Tanguy Seiwert;Tsadik Habtetsion;Gang Zhou;Donastas Sakellariou-Thompson;Cara Haymaker;Caitlin Creasy;Mark Hurd;Naohiro Uraoka;Jaime Rodriguez Canales;Scott Koptez;Patrick Hwu;Anirban Maitra;Chantale Bernatchez;Scott M. Coyle;Kole T. Roybel;Levi J. Rupp;Stephen P. Santoro;Stephanie Secrest;Michael Spelman;Hanson Ho;Tina Gomes;Tiffany Tse;Chia Yung-Wu;Jack Taunton;Wendell Lim;Peter Emtage;Tarsem Moudgil;Carmen Ballesteros-Merino;Traci Hilton;Christopher Paustian;Rom Leidner;David Page;Walter Urba;Bernard Fox;Bryan Bell;Ashish Patel;Tove Olafsen;Daulet Satpayev;Michael Torgov;Filippo Marchioni;Jason Romero;Ziyue Karen Jiang;Charles Zamilpa;Jennifer S. Keppler;Alessandro Mascioni;Fang Jia;Chen-Yu Lee;Jean Gudas;Ryan J. Sullivan;Yujin Hoshida;Theodore Logan;Nikhil Khushalani;Anita Giobbie-Hurder;Kim Margolin;Joanna Roder;Rupal Bhatt;Henry Koon;Thomas Olencki;Thomas Hutson;Brendan Curti;Shauna Blackmon;James W. Mier;Igor Puzanov;Heinrich Roder;John Stewart;Asim Amin;Marc S. Ernstoff;Joseph I. Clark;Michael B. Atkins;Howard L. Kaufman;Jeffrey Sosman;Sabina Signoretti;David F. McDermott;Abraham A. Anderson;Igor Puzanov;Mohammed M. Milhem;Robert H. I. Andtbacka;David Minor;Kevin S. Gorski;Daniel M. Baker;Omid Hamid;Howard L. Kaufman;Emmanuel Akporiaye;Brendan Curti;Yoshinobu Koguchi;Rom Leidner;Kim Sutcliffe;Kristie Conder;Walter Urba;Thomas Marron;Nina Bhardwaj;Linda Hammerich;Fiby George;Seunghee Kim-Schulze;Tibor Keler;Tom Davis;Elizabeth Crowley;Andres Salazar;Joshua Brody;Arta Monjazeb;Megan E. Daly;Jonathan Riess;Tianhong Li;William J. Murphy;Karen Kelly;Zhiwei Hu;Rulong Shen;Amanda Campbell;Elizabeth McMichael;Lianbo Yu;Bhuvaneswari Ramaswam;Cheryl A. London;Tian Xu;William Carson;Kathleen M. Kokolus;Elizabeth A. Repasky;Todd D. Schell;Joseph D. Drabick;David J. Messenheimer;Shawn Jensen;Bernard Fox;Mark Rubinstein;Kristina Andrijauskaite;Marzena Swiderska-syn;Kristin Lind;Agnes Choppin;Marina K. Roell;John Wrangle;Kristina Andrijauskaite;Marzena Swiderska-syn;Peter Rhode;Hing Wong;Mark Rubinstein;Shamim Ahmad;Mason Webb;Rasha Abu-Eid;Rajeev Shrimali;Vivek Verma;Atbin Doroodchi;Zuzana Berrong;David Yashar;Raed Samara;Mikayel Mkrtichyan;Samir Khleif;Steven Powell;Mark Gitau;Christopher Sumey;Andrew Terrell;Michele Lohr;Ryan K. Nowak;Steven McGraw;Ash Jensen;Miran Blanchard;Kathryn A. Gold;Ezra E. W. Cohen;Christie Ellison;Lora Black;John Lee;William Chad Spanos;Erik Wennerberg;Emily Schwitzer;Claire Lhuillier;Graeme Koelwyn;Rebecca Hiner;Lee Jones;Sandra Demaria;Vandeveer Amanda;John W. Greiner;Jeffrey Schlom;Michelle Bookstaver;Christopher M. Jewell;Christopher Paustian;Andrew Gunderson;Brian Boulmay;Rui Li;Bradley Spieler;Kyle Happel;Tarsem Moudgil;Zipei Feng;Carmen Ballesteros-Merino;Christopher Dubay;Brenda Fisher;Yoshinobu Koguchi;Sandra Aung;Eileen Mederos;Carlo B. Bifulco;Michael McNamara;Keith Bahjat;William Redmond;Augusto Ochoa;Hong-Ming Hu;Adi Mehta;Fridtjof Lund-Johansen;Bernard Fox;Walter Urba;Rachel E. Sanborn;Traci Hilton;Frank Bedu-Addo;Greg Conn;Michael King;Panna Dutta;Robert Shepard;Mark Einstein;Sylvia Adams;Ena Wang;Ping Jin;Yelena Novik;Debra Morrison;Ruth Oratz;Franco M. Marincola;David Stroncek;Judith Goldberg;Sandra Demaria;Silvia C. Formenti;Jérôme Galon;Bernhard Mlecnik;Florence Marliot;Fang-Shu Ou;Carlo B. Bifulco;Alessandro Lugli;Inti Zlobec;Tilman T. Rau;Iris D. Nagtegaal;Elisa Vink-Borger;Arndt Hartmann;Carol Geppert;Michael H. Roehrl;Prashant Bavi;Pamela S. Ohashi;Julia Y. Wang;Linh T. Nguyen;SeongJun Han;Heather L. MacGregor;Sara Hafezi-Bakhtiari;Bradley G. Wouters;Yutaka Kawakami;Boryana Papivanova;Mingli Xu;Tomonobu Fujita;Shoichi Hazama;Nobuaki Suzuki;Hiroaki Nagano;Kiyotaka Okuno;Kyogo Itoh;Eva Zavadova;Michal Vocka;Jan Spacek;Lubos Petruzelka;Bohuslav Konopasek;Pavel Dundr;Helena Skalova;Toshihiko Torigoe;Noriyuki Sato;Tomohisa Furuhata;Ichiro Takemasa;Marc Van den Eynde;Anne Jouret-Mourin;Jean-Pascal Machiels;Tessa Fredriksen;Lucie Lafontaine;Bénédicte Buttard;Sarah Church;Pauline Maby;Helen Angell;Mihaela Angelova;Angela Vasaturo;Gabriela Bindea;Anne Berger;Christine Lagorce;Prabhu S. Patel;Hemangini H. Vora;Birva Shah;Jayendrakumar B. Patel;Kruti N. Rajvik;Shashank J. Pandya;Shilin N. Shukla;Yili Wang;Guanjun Zhang;Giuseppe V. Masucci;Emilia K. Andersson;Fabio Grizzi;Luigi Laghi;Gerardo Botti;Fabiana Tatangelo;Paolo Delrio;Gennaro Cilberto;Paolo A. Ascierto;Franco Marincola;Daniel J. Sargent;Bernard A. Fox;Alain Algazi;Katy Tsai;Michael Rosenblum;Prachi Nandoskar;Robert H. I. Andtbacka;Amy Li;John Nonomura;Kathryn Takamura;Mary Dwyer;Erica Browning;Reneta Talia;Chris Twitty;Sharron Gargosky;Jean Campbell;Carmen Ballesteros-Merino;Carlo B. Bifulco;Bernard Fox;Mai Le;Robert H. Pierce;Adil Daud;Robyn Gartrell;Douglas Marks;Edward Stack;Yan Lu;Daisuke Izaki;Kristen Beck;Dan Tong Jia;Paul Armenta;Ashley White-Stern;Yichun Fu;Zoe Blake;Howard L. Kaufman;Bret Taback;Basil Horst;Yvonne M. Saenger;Steven Leonardo;Keith Gorden;Ross B. Fulton;Kathryn Fraser;Takashi O. Kangas;Richard Walsh;Kathleen Ertelt;Jeremy Graff;Mark Uhlik;Jennifer S. Sims;Liang Lei;Takashi Tsujiuchi;Jeffrey N. Bruce;Peter Canoll;Anthony W Tolcher;Evan W Alley;Gurunadh Chichili;Jan E Canoll;Paul Moore;Ezio Bonvini;Syd Johnson;Sadhna Shankar;James Vasselli;Jon Wigginton;John Powderly
通讯作者：
John Powderly

1177: Testicular Cancer Susceptidility and Variants in Androgen Metabolism Genes

DOI：
10.1016/s0022-5347(18)38414-3
发表时间：
2004-04-01
期刊：
Conference abstract
影响因子：
作者：
Katherine L. Nathanson;Peter A. Kanetsky;Richard Letrero;Karina Robertson;Elizabeth E. Ohr;Jeanne Manson;Stanley B. Malkowicz;David J. Vaughn
通讯作者：
David J. Vaughn