STATE CHANGES IN UPPER AIRWAY STRUCTURE AND FUNCTION

上呼吸道结构和功能的状态变化

• 批准号: 6274457
• 负责人: Richard J. Schwab
• 金额: $ 2.5万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274457
• 关键词: biomechanics; clinical research; computer graphics /printing; human subject; magnetic resonance imaging; respiratory airflow disorder; respiratory function; respiratory imaging /visualization; respiratory system; sleep; sleep apnea; wakefulness

The focus of thsi proposal is an understanding of the mechanisms leading to sleep apnea by evaluating the structure and function of the upper airway using state-of-the-art magnetic resonance imaging techniques. We have utilized novel implementations of state-of-the-art dynamic magnetic resonance imaging and tagging techniques coupled with airway structure and function in patients with sleep apnea. These studies have begun to elucidate the biomechanics and compliance of the upper airway, and in particular determine the anatomic structures whose mortion underlies the dimensional changes that take place in the upper airway during respiration, and during airway closure during sleep. Our overall hypothesis is that the key structures mediating changes in airway size during respiration, sleep, and during apneas are the lateral pharyngeal walls. Customized computer graphics-based volumetric image analysis and display methods provide for objective quantitation of teh image data. Improved understanding of the functional and mechanical airway abnormalities in patients with obstructive sleep apnea should lead to new treatment strategies for this disorder.

该提案的重点是了解导致 睡眠呼吸暂停综合征的治疗方法 使用最先进的磁共振成像技术检查气道。 我们利用了最先进的动态 磁共振成像和标记技术结合气道 睡眠呼吸暂停综合征患者的结构和功能。 这些研究 开始阐明上呼吸道的生物力学和顺应性， 特别是确定了那些 是上呼吸道尺寸变化的基础 在呼吸期间以及在睡眠期间的气道闭合期间。我们的整体 一种假说认为，调节气道大小变化的关键结构 在呼吸、睡眠和呼吸暂停期间， 墙 定制的基于计算机图形的体积图像分析和 显示方法提供了图像数据的客观定量。 提高对功能性气道和机械性气道的理解 阻塞性睡眠呼吸暂停综合征患者的异常应导致 新的治疗策略。