Imaging Core

位于肺部成像中心的成像核心将作为中心设施， 处理项目01、02和03生成的大量MRI和MR数据分析。的 成像核心的目标是：1）将数据从MRI传输到肺部成像中心; 2） 确保对MR图像进行正确的数据分析，3）对上气道软组织进行定量分析 和颅面结构，用狄克逊成像和磁共振波谱量化舌脂肪， 量化内脏腹部脂肪，量化LV尺寸和主动脉僵硬度; 4）确保MR的质量控制 5）建立新的计算机分析三维图像分析程序。的MR 图像将通过图像传输器以电子方式传输至肺部成像中心， 通信系统（PACS）。图像分析将在肺部成像中心进行 其中有4个Sun工作站运行一个为 三维图像分析（体积图像显示和分析，维达）。我们还将利用 AMIRA软件-先进的可视化和体积建模，用于数据的体积显示。TheMR 数据分析是复杂的，并且在没有大量训练的情况下不能进行。施瓦布医生一直是 自1991年以来，他一直担任肺成像中心主任，并在分析 这样的数据。大量的MRI证明了建立一个致力于执行 项目01、02和03提出的复杂分析。一个集中的设施将确保质量控制 数据和成本效益。我们将在宾夕法尼亚大学和冰岛进行MRI。 我们已经与冰岛MR团队在NIH资助的大型持续合作中成功合作， 冰岛的一项研究（“阻塞性睡眠呼吸暂停的家族连锁研究”（HL 072067））， 上呼吸道和内脏腹部脂肪的检查已经完成。超过300个核磁共振成像仪已经 被分析。磁共振成像核心将由理查德·施瓦布博士领导 支持人员包括高级研究放射科医生（内脏腹部脂肪（Torigian博士），MR 光谱学（Poptani博士），图像处理，重建和阈值分析（Udupa博士）和两个 研究技术人员执行和验证图像分析。开发中央核心设施， 上呼吸道和腹部内脏脂肪容积成像的专业知识将促进拟议的研究 通过标准化成像分析范例，允许开发新的图像分析方法， 并确保所有三个研究项目的质量保证/可重复性。

The Imaging Core, located in the Pulmonary Imaging Center will act as a central facility to handle and process the large number of MRI's and MR data analysis generated by Projects 01, 02 and 03. The objectives of the Imaging Core are to: 1) transfer data from the MRI to the Pulmonary Imaging Center; 2) ensure proper data analysis of the MR images, 3) perform quantitative analysis of upper airway soft tissue and craniofacial structures on spin echo MRI, quantify tongue fat with Dixon imaging and MR spectroscopy, quantify visceral abdominal fat, quantify LV size and aortic stiffness; 4) ensure quality control of the MR images; and 5) establish new computer analysis three-dimensional image analysis programs. The MR images will be electronically transferred to the Pulmonary Imaging Center via a Picture Archiving and Communication System (PACS). The image analysis will be performed in the Pulmonary Imaging Center where there are 4 Sun workstations running a completely novel software package developed for the analysis of three-dimensional images (Volumetric Image Display and Analysis, VIDA). We will also utilize AMIRA software - Advanced Visualization and Volume Modeling for volumetric display of the data. TheMR data analysis is complicated and cannot be performed without significant training. Dr. Schwab has been the director of the Pulmonary Imaging Center since 1991 and has an established track record for analyzing such data. The large number of MRI's justifies the establishment of a core devoted to the performing the complicated analysis proposed in Projects 01, 02 and 03. A centralized facility will ensure quality control of the data and cost effectiveness. We will perform MRI's at the University of Pennsylvania and in Iceland. We have already had a successful collaboration with the Iceland MR team in a large ongoing NIH funded Icelandic study ("A Family Linkage Study of Obstructive Sleep Apnea" (HL072067)) in which 391 MRI's of the upper airway and of visceral abdominal fat have been performed. Over 300 of these MRI's have already been analyzed. The Magnetic Resonance Imaging Core will be under the leadership of Dr. Richard Schwab with support staff consisting of senior research radiologists (visceral abdominal fat (Dr. Torigian), MR spectroscopy (Dr. Poptani), image processing, reconstruction and threshold analysis (Dr. Udupa) and two research technicians to perform and validate the image analysis. Development of a central core facility with expertise in upper airway and volumetric abdominal visceral fat imaging will facilitate the proposed research by standardizing the imaging analysis paradigms, allow the development of new image analysis approaches and ensure quality assurance/reproducibility across all three research projects.