Imaging Core
Imaging Core
批准号:
7613236
负责人:
Richard J. Schwab
金额:
$28.9万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-07-01 至 2014-06-30
关键词:
AbdomenCollaborationsComputer AnalysisComputer softwareCore FacilityDataData AnalysesData DisplayDevelopmentEnsureFamilyFatty acid glycerol estersFundingHumanIcelandImageImage AnalysisImageryLeadershipMagnetic Resonance ImagingMagnetic Resonance SpectroscopyModelingMonitorObesityObstructive Sleep ApneaPennsylvaniaPicture Archiving and Communication SystemProceduresProcessQuality ControlReproducibilityResearchResearch Project GrantsRodentRoleRunningSleep Apnea SyndromesStandardizationStructureThe SunThree-Dimensional ImageThree-dimensional analysisTongueTrainingUnited States National Institutes of HealthUniversitiesVisceralabdominal fatcost effectivenesscraniofacialendophenotypeimage processinglung imagingnovelprogramsquality assuranceradiologistreconstructionsoft tissue
中文摘要
位于肺成像中心的成像核心将作为中心设施来处理和
英文摘要
The Imaging Core, located in the Pulmonary Imaging Center will act as a central facility to handle and
process the large number of MRI's and MR data analysis generated by Projects 01, 02 and 03. The
objectives of the Imaging Core are to: 1) transfer data from the MRI to the Pulmonary Imaging Center; 2)
ensure proper data analysis of the MR images, 3) perform quantitative analysis of upper airway soft tissue
and craniofacial structures on spin echo MRI, quantify tongue fat with Dixon imaging and MR spectroscopy,
quantify visceral abdominal fat, quantify LV size and aortic stiffness; 4) ensure quality control of the MR
images; and 5) establish new computer analysis three-dimensional image analysis programs. The MR
images will be electronically transferred to the Pulmonary Imaging Center via a Picture Archiving and
Communication System (PACS). The image analysis will be performed in the Pulmonary Imaging Center
where there are 4 Sun workstations running a completely novel software package developed for the
analysis of three-dimensional images (Volumetric Image Display and Analysis, VIDA). We will also utilize
AMIRA software - Advanced Visualization and Volume Modeling for volumetric display of the data. TheMR
data analysis is complicated and cannot be performed without significant training. Dr. Schwab has been the
director of the Pulmonary Imaging Center since 1991 and has an established track record for analyzing
such data. The large number of MRI's justifies the establishment of a core devoted to the performing the
complicated analysis proposed in Projects 01, 02 and 03. A centralized facility will ensure quality control of
the data and cost effectiveness. We will perform MRI's at the University of Pennsylvania and in Iceland.
We have already had a successful collaboration with the Iceland MR team in a large ongoing NIH funded
Icelandic study ("A Family Linkage Study of Obstructive Sleep Apnea" (HL072067)) in which 391 MRI's of
the upper airway and of visceral abdominal fat have been performed. Over 300 of these MRI's have already
been analyzed. The Magnetic Resonance Imaging Core will be under the leadership of Dr. Richard Schwab
with support staff consisting of senior research radiologists (visceral abdominal fat (Dr. Torigian), MR
spectroscopy (Dr. Poptani), image processing, reconstruction and threshold analysis (Dr. Udupa) and two
research technicians to perform and validate the image analysis. Development of a central core facility with
expertise in upper airway and volumetric abdominal visceral fat imaging will facilitate the proposed research
by standardizing the imaging analysis paradigms, allow the development of new image analysis approaches
and ensure quality assurance/reproducibility across all three research projects.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
-
批准号:10555809
-
项目类别:
-
资助金额:$56.74万
-
财政年份:2023
-
负责人:Richard J. Schwab
-
依托单位:
Understanding the relationship between obesity and tongue fat in humans and rats
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批准号:7613226
-
项目类别:
-
资助金额:$28.9万
-
财政年份:2009
-
负责人:Richard J. Schwab
-
依托单位:
Obesity & OSA: Understanding the Importance of Tongue Fat and Metabolic Function
-
批准号:7689181
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项目类别:
-
资助金额:$61.73万
-
财政年份:2008
-
负责人:Richard J. Schwab
-
依托单位:
Obesity & OSA: Understanding the Importance of Tongue Fat and Metabolic Function
-
批准号:7905760
-
项目类别:
-
资助金额:$60.17万
-
财政年份:2008
-
负责人:Richard J. Schwab
-
依托单位:
Obesity & OSA: Understanding the Importance of Tongue Fat and Metabolic Function
-
批准号:7527568
-
项目类别:
-
资助金额:$62.28万
-
财政年份:2008
-
负责人:Richard J. Schwab
-
依托单位:
Obesity & OSA: Understanding the Importance of Tongue Fat and Metabolic Function
-
批准号:8091293
-
项目类别:
-
资助金额:$59.46万
-
财政年份:2008
-
负责人:Richard J. Schwab
-
依托单位:
PATHOGENESIS AND TREATMENT OF OBSTRUCTIVE SLEEP APNEA
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批准号:7199027
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项目类别:
-
资助金额:$0.1万
-
财政年份:2004
-
负责人:Richard J. Schwab
-
依托单位:
Pathogenesis and Genetics of Obstructive Sleep Apnea
-
批准号:7048520
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项目类别:
-
资助金额:$13.95万
-
财政年份:2002
-
负责人:Richard J. Schwab
-
依托单位:
Pathogenesis and Genetics of Obstructive Sleep Apnea
-
批准号:6879996
-
项目类别:
-
资助金额:$13.95万
-
财政年份:2002
-
负责人:Richard J. Schwab
-
依托单位:
Pathogenesis and Genetics of Obstructive Sleep Apnea
-
批准号:6721293
-
项目类别:
-
资助金额:$13.95万
-
财政年份:2002
-
负责人:Richard J. Schwab
-
依托单位:
INTERMEDIATE TRAITS FOR SLEEP APNEA
-
批准号:6657596
-
项目类别:
-
资助金额:$12.63万
-
财政年份:2002
-
负责人:Richard J. Schwab
-
依托单位:
Pathogenesis and Genetics of Obstructive Sleep Apnea
-
批准号:6623402
-
项目类别:
-
资助金额:$13.95万
-
财政年份:2002
-
负责人:Richard J. Schwab
-
依托单位:
Pathogenesis and Genetics of Obstructive Sleep Apnea
-
批准号:6465372
-
项目类别:
-
资助金额:$13.95万
-
财政年份:2002
-
负责人:Richard J. Schwab
-
依托单位:
INTERMEDIATE TRAITS FOR SLEEP APNEA
-
批准号:6501129
-
项目类别:
-
资助金额:$12.63万
-
财政年份:2001
-
负责人:Richard J. Schwab
-
依托单位:
STATE CHANGES IN UPPER AIRWAY STRUCTURE AND FUNCTION
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批准号:6565884
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项目类别:
-
资助金额:$12.41万
-
财政年份:2001
-
负责人:Richard J. Schwab
-
依托单位:
INTERMEDIATE TRAITS FOR SLEEP APNEA
-
批准号:6349173
-
项目类别:
-
资助金额:$21.99万
-
财政年份:2000
-
负责人:Richard J. Schwab
-
依托单位:
STATE CHANGES IN UPPER AIRWAY STRUCTURE AND FUNCTION
-
批准号:6468134
-
项目类别:
-
资助金额:$12.41万
-
财政年份:2000
-
负责人:Richard J. Schwab
-
依托单位:
INTERMEDIATE TRAITS FOR SLEEP APNEA
-
批准号:6202592
-
项目类别:
-
资助金额:$21.99万
-
财政年份:1999
-
负责人:Richard J. Schwab
-
依托单位:
STATE CHANGES IN UPPER AIRWAY STRUCTURE AND FUNCTION
-
批准号:6303376
-
项目类别:
-
资助金额:$2.51万
-
财政年份:1999
-
负责人:Richard J. Schwab
-
依托单位:
STATE CHANGES IN UPPER AIRWAY STRUCTURE AND FUNCTION
-
批准号:6113223
-
项目类别:
-
资助金额:$2.51万
-
财政年份:1998
-
负责人:Richard J. Schwab
-
依托单位:
海外基金