GROWTH FACTORS, SLEEP AND COGNITION II

生长因素、睡眠和认知 II

• 批准号: 6274341
• 负责人: MICHAEL V. VITIELLO
• 金额: $ 2.06万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274341
• 关键词: aging; clinical research; cognition; estrogens; gender difference; growth hormone releasing hormone; hormone therapy; human subject; insulinlike growth factor; sleep; somatotropin

We propose to examine the effects of five months of treatment with GEREF vs. placebo on the sleep quality, 24-hour secretory pattern of growth hormone, and insulin-like growth factor-1 concentrations of three groups of healthy older subjects: men, women not on estrogen replacement therapy and women on estrogen replacement therapy. The inclusion of women on ERT as a separate group is important because estrogen interacts in numerous ways wiht the GH-IGF-1 axis and because an increasing proportion of older women are on chronic ERT.

我们建议研究用GEREF治疗5个月的效果