CORE-- CLINICAL

加州大学戴维斯分校阿尔茨海默病中心(UCD ADC)的临床核心 寻求促进对北加州阿尔茨海默氏症的研究 通过为调查人员创建一个经过仔细评估的集中来源 和特征良好的痴呆症患者和正常对照组 维护有关这些疾病的临床和神经病理学研究结果的数据库 研究对象。UCD ADC有一个大而多样的集水区， 包括旧金山、旧金山的主要城市和郊区 何塞、奥克兰和萨克拉门托，农业中心的大部分地区 山谷，以及东部和北部的农村地区。患者被转诊自 加州大学戴维斯分校诊所和设施的广泛网络连接到4个ADC 演出地点；2个主要诊所(伯克利和萨克拉门托)和2个 卫星诊所(奥克兰和约洛县)。临床核心提供 整合这些临床痴呆症评估的资源和人员 将这些设施整合为一个具有共同研究任务的综合计划。 核心的主要职能是：1)创建一个种族多元化的 由仔细诊断并具有良好特征的受试者组成 痴呆症患者和正常对照组，2)收集综合和 这些受试者的标准化临床数据，3)创建和管理 诊断、临床和神经病理学发现的中央数据库， 4)提供纵向跟踪；5)通过 为特定研究确定和招募患者和对照，以及 6)运营卫星诊所，方便少数族裔和 对未得到充分服务的人群进行阿尔茨海默病研究。《核心》 招募和评估人口统计学上匹配的对照受试者 与患者相同的方案和方法，并投入了相当多的 注意跨站点和评核人之间的可靠性问题，以及 开发用于量化临床数据的创新方法。 最后，核心促进了对研究感兴趣的患者的尸检。 在这次更新中，临床核心提出了进化修改的建议 它在第一个供资周期中采用的方法。核心意志 每年评估约300名新患者和100名新对照 获得标准化病史，神经学检查，神经成像， 所有患者的实验室、神经心理学、行为和精神病学数据。 它将维持其约300名患者的纵向队列 都是高质量的研究主题，并创造了可比的纵向 对200名同意尸检的对照受试者进行随访。 中心的两个卫星诊所已经发展出有效的外展方法 导致相当数量的少数民族患者； 核心将建立在这个临床基础上，以实现种族 多样化和平衡的研究和尸检样本。所有受试者的数据 将被输入到一个广泛的数据库中，核心将帮助招募 这些课题在个人研究项目中，跟踪研究 参与，并帮助获得尸检。

The Clinical Core of the UC Davis Alzheimer's Disease Center (UCD ADC) seeks to facilitate research on Alzheimer's disease in Northern California by creating for investigators a centralized source of carefully evaluated and well characterized dementia patients and normal controls and maintaining a database of clinical and neuropathological findings on these subjects. The UCD ADC has a large and diverse catchment area, encompassing the major cities and suburban areas of San Francisco, San Jose, Oakland, and Sacramento, large portions of the agricultural Central Valley, and rural areas to the east and north. Patients are referred from an extensive network of UC Davis clinics and facilities to 4 ADC performance sites; 2 main clinics (Berkeley and Sacramento) and 2 satellite clinics (Oakland and Yolo County). The Clinical Core provides the resources and personnel to combine these clinical dementia evaluation facilities into an integrated program with a shared research mission. The major functions of the Core are: 1) to create an ethnically diverse subject pool consisting of carefully diagnosed and well characterized dementia patients and normal controls, 2) to collect comprehensive and standardized clinical data on these subjects, 3) to create and manage a central database of diagnostic, clinical, and neuropathological findings, 4) to provide longitudinal follow-up, 5) to support research by identifying and recruiting patients and controls for specific studies, and 6) to operate satellite clinics to facilitate access of minority and under-served populations to Alzheimer's disease research. The Core recruits and evaluates demographically matched control subjects using the same protocols and methods as for patients and devotes considerable attention to issues of cross-site and inter-rater reliability, and to the development of innovative methods for quantitating clinical data. Finally, the Core facilitates autopsy for patients of research interest. In this renewal the Clinical Core proposes evolutionary modifications of the methods it employed in its first funding cycle. The Core will evaluate approximately 300 new patients and 100 new controls per year obtaining standardized histories, neurological exams, neuroimaging, laboratory, neuropsychological, behavioral and psychiatric data on all. It will maintain its longitudinal cohort of approximately 300 patients who are high quality research subjects and create a comparable longitudinal follow-up cohort of 200 control subjects who have consented to autopsy. The Core's two satellite clinics have evolved effective outreach methods which have resulted in substantial numbers of ethnic minority patients; the Core will build upon this clinical base to achieve an ethnically diverse and balanced research and autopsy sample. Data from all subjects will be entered to an extensive database and the Core will help enlist these subjects in individual research projects, track research participation, and help obtain autopsy.