LONGITUDINAL STUDIES OF AD AND SIVD

AD 和 SIVD 的纵向研究

• 批准号: 7458885
• 负责人: DAN M. MUNGAS
• 金额: $ 32.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7458885
• 关键词: Accounting; Address; Affect; Alzheimer' s Disease; Brain; Cerebrovascular Disorders; Cognition; Cognitive; Data; Dementia; Diagnosis; Disease Marker; Elderly; Enrollment; Evaluation; Hippocampus (Brain); Impaired cognition; Impairment; Lesion; MRI Scans; Magnetic Resonance Imaging; Measures; Memory; Methods; Pathology; Patients; Program Research Project Grants; Purpose; Rate; Source; Testing; cerebral atrophy; design; executive function; follow-up; functional decline; functional disability; gray matter; hippocampal atrophy; neuroimaging; neuropathology; neuropsychological; white matter

The purpose of this project is to better characterize independent and interactive contributions to dementia of AD and sCVD. This project will use common, core data that is available for all subjects enrolled in the overall program project grant (PPG). It will focus on global and specific cognitive abilities and independent functioning as dependent variables and will incorporate date from longitudinal follow-up and neuropathology to address questions about additive and interactive effects of AD and sCVD in determining presentation and progression of dementia. Mechanisms of cognitive and functional change in AD and sCVD will be examined using cross sectional, longitudinal, and pathological data. Multiple replications wilt be accomplished by performing the same analyses using data from these three sources so that convergence of timings can be directly compared. The availability of data from neuropathology will allow for a critical form of replication. Hypotheses to be tested in this project are: 1) Cognitive and functional impairment in sCVD and AD are primarily due to loss of volume of cortical gray matter and hippocampus, 1a) Memory is primarily related to hippocampal volume and executive function to frontal cortical gray matter volume, 1b) Predicted relationships from Hypothesis 1 will be supported in neuropathology diagnosed cases without AD and independently in pathology diagnosed cases with AD, 2) sCVD and AD neuropathology measures and MRI markers of these pathologies will make additive and independent contributions to cognitive impairment and dementia, and 3) Progression to dementia in non-demented cases at initial evaluation will be strongly predicted by MRI markers of AD pathology and weakly predicted by markers of sCVD pathology.

该项目的目的是更好地表征AD和sCVD对痴呆的独立和交互作用。该项目将使用通用的核心数据，这些数据适用于所有参加总体项目资助（PPG）的受试者。它将侧重于全球和特定的认知能力和独立功能作为因变量，并将纳入纵向随访和神经病理学的数据，以解决有关AD和sCVD在确定痴呆的表现和进展方面的叠加和交互作用的问题。AD和sCVD的认知和功能变化的机制将使用横截面，纵向和病理学数据进行检查。将通过以下方式完成多次复制 使用来自这三个来源的数据执行相同的分析，以便可以直接比较时间的收敛。神经病理学数据的可用性将允许复制的关键形式。本项目中要检验的假设是：1）sCVD和AD中的认知和功能损害主要是由于皮质灰质和海马体积的损失。1a）记忆主要与海马体积相关，执行功能与额叶皮质灰质体积相关，（b）来自假设1的预测关系将在无AD的神经病理学诊断病例中得到支持，并且在病理学诊断病例中得到独立支持2）sCVD和AD神经病理学测量和这些病理学的MRI标记物将对认知障碍做出累加和独立的贡献， 痴呆，和3）在初始评估时，非痴呆病例进展为痴呆将被AD病理学的MRI标志物强预测，而被sCVD病理学的标志物弱预测。