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GROWTH HORMONE RECEPTORS AND ACTIONS

GROWTH HORMONE RECEPTORS AND ACTIONS
生长激素受体和作用
批准号:
6274726
负责人:
CHRISTIN CARTER-SU
金额:
$2.15万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30

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英文摘要
Growth hormone (GH) promotes the tyrosyl phosphorylation of its receptor and other cellular proteins. Tyrosine kinase activity also co-purifies with the GH receptor. These results suggest that activation by GH of a GH receptor-associated tyrosine kinase may be an important step in the signal transduction mechanism for GH. Our research is now focused upon cloning the GH receptor-associated tyrosine kinase and using in vitro mutagenesis to determine its role in celluar actions of GH.
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