OLDER PERSONS AND DRUGS--CALCIUM BLOCKER KINETICS/DYNAMICS

老年人和药物——钙阻滞剂动力学/动力学

• 批准号: 6275294
• 负责人: JANICE B SCHWARTZ
• 金额: $ 2.26万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275294
• 关键词: aging; calcium channel blockers; cardiovascular disorder chemotherapy; clinical research; drug screening /evaluation; human old age (65+); human subject; outcomes research; pharmacokinetics

Determining the mechanisms responsible for altered drug responses in the elderly to develop more effective drug therapy is the long term goal of this investigator. Because cardiovascular diseases are the most prevalent in older patients and cardiovascular drugs are the most frequently prescribed therapeutic agents in older patients, and because of the potential for widespread use of calcium blocker drugs in elderly patients with cardiovascular disease, aging effects on calcium channel blocker pharmacokinetics and pharmacodynamics have been chosen.

确定导致药物反应改变的机制 开发更有效的老年人药物治疗方法是长期目标 这位调查员。因为心血管疾病是最常见的 在老年患者中，心血管药物是最常见的 为老年患者开出治疗药物，并且由于 钙阻滞剂药物在老年患者中广泛使用的潜力 与心血管疾病、衰老对钙通道阻滞剂的影响 选择了药代动力学和药效学。