LATITUDE WITHIN AN NCEP STEP I DIET--AN OPTIMAL DIET

NCEP 第 I 步饮食中的宽容度——最佳饮食

• 批准号: 6276305
• 负责人: JOHN W FARQUHAR
• 金额: $ 4.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276305
• 关键词: arginine; ascorbate; cardiovascular disorder prevention; carotenoids; clinical research; clinical trials; coronary disorder; diet therapy; dietary carbohydrates; dietary fiber; dietary lipid; disease /disorder proneness /risk; flavonoids; folate; human subject; human therapy evaluation; insulin; low density lipoprotein; nutrition related tag; phytoestrogens; saturated fat; tocopherols; unsaturated fats; vascular endothelium; vegetarian diet

The objective of the study is to examine whether the potential public health impact on coronary heart disease (CHD) risk reduction of an NCEP/AHA Step One Diet may currently be underestimated because of an overemphasis on the avoidance of fat and cholesterol and an underemphasis on the inclusion of plant-based foods. A large number of dietary factors in plant based foods have been linked to the reduction of various CHD risk factors. However, the food industry's production of thousands of new "reduced-fat" food products over the last decade has now made it possible to follow a Step One Diet with a foundation in low-fat commercial foods (that are often high in calories) rather than plant-based foods. We will design two diets that both meet NCEP/AHA Step One Diet guidelines and are matched on total fat, saturated fat, monounsaturated fat, polyunsaturated fat, cholesterol, protein and total carboyhydrate. One diet will include a large proportion of plant-based foods, and will be relatively higher in content of plant protein, arginine, complex carbohydrates, soluble and insoluble fiber, Vitamins E, C and folate, carotenoids, phytosterols, phytoestrogens, flavonoids, allicin and saponins (NCEP-Plus). The other diet will include a large proportion of commercially available reduced-fat products and will be relatively higher in animal protein, simple carbohydrates and trans fatty acids (NCEP-Low).

这项研究的目的是探讨潜在的公众是否 降低冠心病风险对健康的影响 NCEP/AHA第一步饮食目前可能被低估，因为 过分强调避免脂肪和胆固醇， 对植物性食品的纳入认识不足。大量的 植物性食物中的饮食因素与 各种CHD危险因素。然而，食品工业的生产 在过去的十年里，成千上万的新的“减脂”食品 现在已经有可能遵循第一步饮食的基础， 低脂肪的商业食品（通常是高热量的），而不是 植物性食物我们将设计两种饮食，都符合NCEP/AHA 第一步饮食指南和匹配的总脂肪，饱和脂肪， 单不饱和脂肪，多不饱和脂肪，胆固醇，蛋白质和总 碳水化合物一种饮食将包括大比例的植物性食物 食物中，植物蛋白的含量会相对较高， 精氨酸，复合碳水化合物，可溶性和不溶性纤维，维生素 维生素E、维生素C和叶酸，类胡萝卜素，植物甾醇，植物雌激素，类黄酮， 大蒜素和皂苷（NCEP-Plus）。另一种饮食将包括一个大的 比例的市售减脂产品，并将 动物性蛋白质、简单碳水化合物和反式 脂肪酸（NCEP-低）。