LATITUDE WITHIN AN NCEP STEP ONE DIET--PILOT STUDY

NCEP 第一步饮食中的宽容度——试点研究

• 批准号: 6246203
• 负责人: JOHN W FARQUHAR
• 金额: $ 3.61万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-15 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246203
• 关键词: adult human (21+); analytical chemistry; cholesterol; clinical research; clinical trials; diet therapy; dietary lipid; dietary restriction; fruit; human subject; human therapy evaluation; low density lipoprotein; nutrition related tag; plant proteins; vegetables

The objective of the study is to examine whether the potential public health impact on coronary heart disease (CHD) risk reduction of an NCEP/AHA Step One Diet may currently be underestimated because of an overemphasis on the avoidance of fat and cholesterol and an underemphasis on the inclusion of plant-based foods. A large number of dietary factors in plant-based foods have been linked to the reduction of various CHD risk factors. However, the food industry's production of thousands of new "reduced-fat" food products over the last decade has now made it possible to follow a Step One diet with a foundation in low- fat commercial foods (that are often high in calories) rather than plant-based foods. We will design two diets that both meet NCEP/AHA Step One Diet guidelines and are matched on total fat, saturated fat, monounsaturated fat, polyunsaturated fat, cholesterol, protein and total carbohydrate. One diet will include a large proportion of plant-based foods, and will be relatively higher in content of plant protein, arginine, complex carbohydrates, soluble and insoluble fiber, Vitamins E, C and folate, carotenoids, phytosterols, phytoestrogens, flavonoids, allicin and saponins (NCEP-Plus). The other diet will include a large proportion of commercially available reduced-fat products and will be relatively higher in animal protein, simple carbohydrates nad trans fatty acids (NCEP-Low). In a clinical trial using a parallel design, seventy adults with moderately elevated LDL-cholesterol (LDL-C 130-190 mg/dL) will be randomized to one of the two diets for four weeks. All meals will be provided. The composition of the two study diets will be determined by chemical analysis. The primary study endpoints will include fasting serum levels of LDL-C, insulin and homocysteine, blood pressure, and in vitro susceptibility of LDL to oxidative degradation, monocyte adhesion, and endothelial function. Our intentions are to examine whether a focus on avoiding fat and cholesterol rather that including plant-based foods result in underestimating the potential health benefits of an NCEP/AHA Step One Diet, and to determine the magnitude of favorable changes in an overall CHD risk factor profile that can be achieved by using current nutrition knowledge to design an "optimal" overall diet.

这项研究的目的是检查潜在的公众 健康对降低冠心病(CHD)风险的影响 NCEP/AHA第一步饮食目前可能被低估，因为 过分强调避免脂肪和胆固醇以及 不重视包括植物性食品。大量的 植物性食品中的饮食因素与这种减少有关 各种冠心病危险因素。然而，食品行业的生产 在过去的十年里，数以千计的新的“减脂”食品 现在有可能遵循第一步节食，基础是低- 脂肪商业食品(通常卡路里含量高)，而不是 植物性食品。我们将设计两种同时满足NCEP/AHA的饮食 第一步饮食指南和总脂肪、饱和脂肪、 单不饱和脂肪、多不饱和脂肪、胆固醇、蛋白质和总脂肪 碳水化合物。一种饮食将包括很大比例的植物性食物 食物，植物蛋白含量会相对较高， 精氨酸、复合碳水化合物、可溶性和不溶性纤维、维生素 E，C和叶酸，类胡萝卜素，植物甾醇，植物雌激素，类黄酮类， 大蒜素和皂苷(NCEP-Plus)。另一种饮食将包括一大块 商业上可获得的减脂产品的比例，并将 相对较高的动物蛋白、简单碳水化合物和反式 脂肪酸(NCEP-低)。 在一项使用平行设计的临床试验中，70名成年人患有 中度升高的低密度脂蛋白-胆固醇(低密度脂蛋白-C 130-190毫克/分升) 随机接受两种饮食中的一种，为期四周。所有的餐点都是 如果是这样的话。这两种研究饮食的组成将由以下因素决定 化学分析。主要研究终点将包括禁食 血清低密度脂蛋白、胰岛素和同型半胱氨酸水平、血压和 低密度脂蛋白对氧化降解、单核细胞黏附、 和内皮功能。我们的意图是检查一个焦点是否 避免脂肪和胆固醇，而不是包括植物性食物 导致低估了NCEP/AHA的潜在健康益处 第一步饮食，并确定有利变化的幅度 可通过使用CURRENT实现的整体CHD风险因素概况 营养知识，以设计一个“最佳”的整体饮食。