HOMOCYSTEINE DIET STUDY: EFFECTS OF DIFFERENT FOLATE SOURCES

同型半胱氨酸饮食研究：不同叶酸来源的影响

• 批准号: 6264336
• 负责人: JOHN W FARQUHAR
• 金额: $ 0.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264336
• 关键词: blood chemistry; clinical research; diet; dietary constituent; dietary supplements; folate; food additives; homocysteine; homocystinuria; human subject; metabolism; nutrition related tag; placebos

The study objective is to determine the effect of three different sources of folic acid (folate) intake on plasma homocysteine levels in a study population with moderately elevated homocysteine levels. The three sources will be (1) a B-vitamin supplement, (2) foods fortified with folic acid, and (3) foods naturally abundant in folic acid. Participants will be assigned to one of these three groups, or a placebo group who will receive in inactive placebo. Study duration will be 12-weeks. Homocysteine levels will be measured weekly for the first 6 weeks, then at week #9 and again at end study at week #12. Therefore, we will study not only the magnitude of the change elicited by the intervention, but also the timecourse. This outpatient study will make use of the GCRC facilities for patient care related to blood sampling, aliquoting, and storing of samples. Participants will provide there own food sources of folate, according to instructions received in weekly nutrition workshops. The two groups receiving either B-vitamin supplementation or placebo will be provided with tablets for the full 12-weeks. Since the group consuming folate rich foods (not folate fortified foods) is likely to increase their intake of fiber and other potential cholesterol lowering dietary agents, we will also measure plasma cholesterol at weeks #1, #6 and #12. As a measure of compliance, we will measure plasma folate levels as well. Implications: For individuals with hyperhomocysteinemia who have been advised to increase their folate intake, this will help to determine which of several approches for increasing folate is most effective.

研究目的是确定三种不同来源的叶酸摄入量对同型半胱氨酸水平中度升高的研究人群血浆同型半胱氨酸水平的影响。这三种来源是 (1) B 族维生素补充剂，(2) 叶酸强化食品，以及 (3) 天然富含叶酸的食品。参与者将被分配到这三组之一，或安慰剂组，他们将接受非活性安慰剂。学习时间为12周。前 6 周每周测量同型半胱氨酸水平，然后在第 9 周测量，并在第 12 周研究结束时再次测量。因此，我们不仅要研究干预引起的变化的幅度，还要研究干预的时间进程。这项门诊研究将利用 GCRC 设施进行与血液采样、等分和样品储存相关的患者护理。参与者将根据每周营养研讨会上收到的说明提供自己的叶酸食物来源。接受 B 族维生素补充剂或安慰剂的两组将在整个 12 周内服用药片。由于食用富含叶酸的食物（不是叶酸强化食品）的人群可能会增加纤维和其他潜在的降低胆固醇饮食剂的摄入量，因此我们还将在第 1、6 和 12 周测量血浆胆固醇。作为依从性的衡量标准，我们还将测量血浆叶酸水平。意义：对于被建议增加叶酸摄入量的高同型半胱氨酸血症患者，这将有助于确定几种增加叶酸的方法中哪一种最有效。