QUANTIFY RETENTION OF NONOXYNOL IN OPEN LABEL, RANDOMIZED CROSS OVER STUDY

量化开放标签、随机交叉研究中壬苯酚的保留量

• 批准号: 6275529
• 负责人: PATRICIA A BARDITCH-CROVO
• 金额: $ 2.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275529
• 关键词: clinical research; clinical trials; communicable disease control; dosage forms; drug administration rate /duration; drug administration routes; female; human subject; nonoxynol 9; pharmacokinetics; sexually transmitted diseases; vagina

This is an open label, randomized, multiple dose study to quantify the amount of Nonoxynol-9 (N-9) retained in the vagina at selected timepoints after instillation. Five different formulations will be studied (foam, 2 types of gel, cellophane, and suppository). For each formulation studied, at least 4 timepoints of retention (2 hr, 4 hr, 8 hr, and 12 hrs) will be studied. For the AdvantageR gel formulation, a 24 hour timepoint will also be studied.

这是一项开放标签，随机，多剂量的研究来量化