Docking, and lipid functions in membrane fusion

膜融合中的对接和脂质功能

• 批准号: nhmrc : GNT1065328
• 负责人: Prof Jens Coorssen
• 金额: $ 37.34万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/docking-lipid-functions-membrane-fusion/1344881
• 关键词: Docking; lipid; functions; membrane; fusion

Understanding and harnessing the fundamental cellular process of secretion will provide a wealth of new approaches to addressing problems associated with aging & disorders that are major health care burdens (e.g. neurodegeneration & diabetes). Understanding the vesicle docked state, and the contributions of different molecular components to the release process provides for unique insights into the underlying molecular mechanisms, thereby enabling safe, targeted control of this critical process.

了解和利用基本的细胞分泌过程将为解决与衰老和疾病相关的问题（例如神经退行性疾病和糖尿病）提供大量新方法，这些问题是主要的医疗负担。了解囊泡对接状态以及不同分子成分对释放过程的贡献，可以为潜在的分子机制提供独特的见解，从而能够安全、有针对性地控制这一关键过程。