Membrane attachment and components of the Ca2+ -triggered release mechanism

Ca2 触发释放机制的膜附件和组件

• 批准号: nhmrc : 1065328
• 负责人: Prof Jens Coorssen
• 金额: $ 25.77万
• 依托单位: University of Western Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/membrane-attachment-components-release-mechanism/455162
• 关键词: Membrane; attachment; components; Ca2+; triggered

Understanding and harnessing the fundamental cellular process of secretion will provide a wealth of new approaches to addressing problems associated with aging & disorders that are major health care burdens (e.g. neurodegeneration & diabetes). Understanding the vesicle docked state, and the contributions of different molecular components to the release process provides for unique insights into the underlying molecular mechanisms, thereby enabling safe, targeted control of this critical process.

了解和利用基本的细胞分泌过程将提供大量新的方法来解决与衰老相关的问题和疾病，这些疾病是主要的医疗保健负担（例如神经变性和糖尿病）。了解囊泡对接状态，以及不同分子组分对释放过程的贡献，提供了对潜在分子机制的独特见解，从而能够安全，有针对性地控制这一关键过程。