FEEDING STRATEGIES FOR LOW BIRTH WEIGHT INFANTS II

我们最初研究的数据表明，人类乳汁的数量 进食对迟发性脓毒症的发病率有显著影响 和/或坏死性小肠结肠炎(NEC)、住院时间、 以及早产儿的成长。拟议的研究将 调查迟发性脓毒症和/或NEC的发生率和病程 两项早产喂养的随机试验的住院率 婴儿强化母乳，添加任何强化的 经巴氏灭菌的供体母乳或早产配方奶粉，并在非 强化母乳与早产配方奶粉的随机比较。 将母乳喂养与较低风险联系起来的一个潜在机制 在感染中，母体的病原体特异性功能滴度 抗体，将被测量。这些婴儿将被跟踪3年 确定母乳喂养的长期后遗症 住院治疗。因为许多母亲没能提供 有足够的牛奶来满足婴儿的需求，将对母亲进行研究 确定不同减压方法对产奶量的影响。 母婴皮肤接触的常见托儿所做法 将评估婴儿对母体功能性抗体的影响 滴度和产奶量。德克萨斯州托儿所的婴儿 未满30周的儿童医院将被录取 妊娠--晚发性疾病风险最高的人群 脓毒症和/或NEC。我们用强化母乳这个术语来表示 母亲自己的乳汁中含有商业蛋白质制剂， 加入矿物质、维生素和葡萄糖聚合物。

Data from our original study suggest that the quantity of human milk consumed had a marked effect on the incidence of late-onset sepsis and/or necrotizing enterocolitis (NEC), the duration of hospitalization, and the growth of the premature infant. The proposed study will investigate the incidence of late-onset sepsis and/or NEC and duration of hospitalization in both a randomized trial of feeding premature infants fortified human milk supplemented with either fortified pasteurized donor human milk or preterm formula, and in a non- randomized comparison between fortified human milk and preterm formula. One potential mechanism to relate human milk feeding to a lower risk of infection, the maternal titer of pathogen-specific functional antibody, will be measured. The infants will be followed for 3 years to determine the long-term sequelae related to feeding human milk during hospitalization. Because of the failure of many mothers to provide sufficient milk to meet their infants' needs, mothers will be studied to determine the effect of stress reduction methods on milk production. The common nursery practice of skin-to-skin contact between mother and infant will be evaluated for its effect on maternal functional antibody titers and milk production. Infants from the nurseries at Texas Children's Hospital will be enrolled if they are less than 30 weeks gestation, the group with the highest risk of developing late-onset sepsis and/or NEC. We use the term fortified mother's milk to indicate mother's own milk to which a commercial preparation of protein, minerals, vitamins, and glucose polymers is added.