FEEDING STRATEGIES FOR LOW BIRTH WEIGHT INFANTS II

低出生体重婴儿的喂养策略 II

• 批准号: 6306266
• 负责人: RICHARD J. SCHANLER
• 金额: $ 3.6万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6306266
• 关键词: bacterial disease; blood toxicology; clinical research; colitis; diet therapy; dietary carbohydrates; dietary mineral; dietary proteins; dietary supplements; glucose; hospital length of stay; human milk; human subject; longitudinal human study; low birth weight infant human; milk; mother child interaction; nutrient intake activity; nutrition related tag; patient care management; vitamin therapy

Data from our original study suggest that the quantity of human milk consumed had a marked effect on the incidence of late-onset sepsis and/or necrotizing enterocolitis (NEC), the duration of hospitalization, and the growth of the premature infant. The proposed study will investigate the incidence of late-onset sepsis and/or NEC and duration of hospitalization in both a randomized trial of feeding premature infants fortified human milk supplemented with either fortified pasteurized donor human milk or preterm formula, and in a non- randomized comparison between fortified human milk and preterm formula. One potential mechanism to relate human milk feeding to a lower risk of infection, the maternal titer of pathogen-specific functional antibody, will be measured. The infants will be followed for 3 years to determine the long-term sequelae related to feeding human milk during hospitalization. Because of the failure of many mothers to provide sufficient milk to meet their infants' needs, mothers will be studied to determine the effect of stress reduction methods on milk production. The common nursery practice of skin-to-skin contact between mother and infant will be evaluated for its effect on maternal functional antibody titers and milk production. Infants from the nurseries at Texas Children's Hospital will be enrolled if they are less than 30 weeks gestation, the group with the highest risk of developing late-onset sepsis and/or NEC. We use the term fortified mother's milk to indicate mother's own milk to which a commercial preparation of protein, minerals, vitamins, and glucose polymers is added.

我们最初的研究数据表明， 食用对迟发性败血症的发生率有显着影响 和/或坏死性小肠结肠炎（NEC），住院时间， 和早产儿的生长。拟定的研究将 研究迟发性脓毒症和/或NEC的发生率和持续时间 在一项随机试验中， 婴儿强化母乳， 巴氏灭菌的供体人乳或早产儿配方，以及在非- 强化母乳和早产儿配方奶粉之间的随机比较。 母乳喂养与低风险相关的一种潜在机制 感染时，母体特异性病原体功能滴度 抗体，将被测量。 这些婴儿将被随访3年 以确定与母乳喂养相关的长期后遗症， 住院由于许多母亲未能提供 为了给婴儿提供足够的母乳， 以确定压力缓解方法对产奶量的影响。 通常的育儿做法是母亲和婴儿之间的皮肤接触， 评价婴儿对母体功能性抗体影响 滴度和产奶量。德克萨斯州托儿所的婴儿 如果不足30周，将纳入儿童医院 妊娠期，晚发型糖尿病风险最高的人群 败血症和/或NEC。我们用强化母乳这个词来表示 母亲自己的牛奶，其中商业制备的蛋白质， 添加矿物质、维生素和葡萄糖聚合物。