TREATMENT OF JUVENILE RHEUMATOID ARTHRITIS WITH ORAL BOVINE TYPE II COLLAGEN

我们建议研究II型口服给药的效果。 活动期JRA患儿的胶原蛋白。这将是第一阶段，而且有限 第二阶段，排除服用DMARDS的儿童的研究。我们建议 包括安慰剂组，并对研究进行盲化，以便任何临床 观察会有最小的偏差。实验室数据将收集到 检查安全性、对炎症活动的总体影响和自身免疫 II型胶原蛋白。

We propose to investigate the effects of oral administration of type II collagen in children with active JRA. This will be a Phase I, and limited Phase II, study which will exclude children taking DMARDs. We propose to include a placebo group and blind the study so that any clinical observation will be minimally bias. Laboratory data will collected to examine safety, overall effect on inflammatory activity, and autoimmunity to type II collagen.