CYTOKINE CASCADE IN BLOOD & CENTRAL NERVOUS SYSTEM

目的：考察细胞因子对药物释放的影响。 外周血和鞘内可溶性介质的含量 车厢。结果白介素1(IL-1)等细胞因子 内源性细胞因子释放的有效刺激因子和 神经内分泌轴，因此在 免疫系统和大脑之间的通讯。我们一直在 研究IL-1对其他细胞因子的影响，如 白细胞介素6，在外周血液和鞘内隔室。 在我们证明IL-6从体内释放出来之后 在中枢神经系统内，我们一直在研究初级细胞 消息来源。此外，我们一直在调查在多大程度上 皮质类固醇参与调节促炎反应。 反应，这与治疗中类固醇的使用有关 脓毒症和过敏性休克。我们未来的研究方向是 现在关注的是血脑屏障的内皮细胞。为了这个 项目，我们已经建立了内皮细胞培养，将 允许研究继续进行血脑屏障的体外模拟。 关键词细胞因子、白介素1、白介素6脑脊液 心理神经免疫学NSF博士前研究员，NIMH MH41659

OBJECTIVE: To examine the influence of cytokines on the release of soluble mediators in the peripheral blood and intrathecal compartments. RESULTS Cytokines, such as interleukin-1 (IL-1), are potent stimulators of endogenous cytokine release and the neuroendocrine axis, and thus play an important role in the communication between the immune system and the brain. We have been investigating the influence of IL-1 on other cytokines, such as interleukin-6, in the peripheral blood and intrathecal compartments. Following our demonstration that IL-6 is released endogenously from within the CNS, we have been investigating the primary cellular source. In addition, we have been investigating the degree to which corticosteroids are involved in modulating the proinflammatory responses, which has bearing on the use of steroids in the treatment of sepsis and anaphylactic shock. FUTURE DIRECTIONS Our studies are now focused on endothelial cells of the blood-brain-barrier. For this project, we have established endothelial cell cultures that will permit the research to go forward with in vitro modelling of the BBB. KEY WORDS cytokines, interleukin-1, interleukin-6 cerebrospinal fluid, psychoneuroimmunology NSF Predoctoral fellowship, NIMH MH41659