BONE REGENERATION MOLECULAR BIOLOGY TO PATIENT TREATMENT

骨再生分子生物学对患者治疗的影响

• 批准号: 2711864
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2711864
• 关键词: Mammalia; Primates; bioengineering /biomedical engineering; biological products; biomaterials; human tissue; model design /development; oral pharyngeal; prosthesis; surgery

Members of this team have been involved in a Program Project describing placement of implants in a primate model and examining bone regeneration from a clinical, radiographic and histological perspective. In addition, the regeneration data have been examined for the release of growth factors and cytokines. Data obtained indicate that 1. Bone generation with membranes in the mandibles of non-human primates is feasible,; 2. Regenerated bone is mature from a histological level at 12 months post-membrane; 3. Bone regenerated with membranes can support a prosthesis; 4. The regenerated bone created will not atrophy; and 5. Lipid anabolic mediators are preceding growth factor expression. The original team has been joined by Dr. Boden of Emory Spine Center, involved with the use of BMP in spinal repair in primates, and by Drs. Nerem and Guldberg, bioengineers from Georgia Institute of Technology, to study bone growth in an artificial chamber and to develop delivery systems. The biostatistical evaluation and community outreach of the Rollins School of Public Health at Emory University and the leveraged funding of an experienced venture capital group will also be described. The specific aims of the proposal are to develop a team to study the following 1. Development of a time released delivery system capable of delivering cytokines and growth factors at intervals to accelerate bone regeneration. Regeneration will be measured initially in a one chamber, followed by tests in rabbits, primate jaw and spine; 2. Bone regeneration will be tested in clinical trials on humans in jaws for the implant placement and in spinal surgery; 3. Community outreach of these data will be monitored by the Rollins School of Public Health; and 4. Teaching of the techniques to professionals will be done at Schools of Dentistry at UNC at Chapel Hill and UAB and at the Spinal Center of Emory University. The health related implications are 1. To be able to rapidly augment bone in the jaws for placement of dentures, removable prostheses, and/or implants, plus reconstruct jaw bone lost after surgery for cancer; 2. To reconstruct bone rapidly in the spine; 3. To disseminate information to the medical and dental communities, as well as to the general public; and 4. To leverage funding with the involvement of an experienced venture capital group. P51RR00165-36 1/1/1996-12/31/1996 Yerkes Regional Primate Research Center

该团队的成员参与了一个计划项目 描述了植入物在灵长类动物模型中的放置 从临床，放射学和组织学的再生 perspective. 此外，还对再生数据进行了检验 来释放生长因子和细胞因子。 获得的数据 表示1. 下颌骨的膜性骨生成 非人灵长类动物是可行的; 2. 再生骨是从 膜后12个月的组织学水平; 3. 骨再生 用膜可以支撑假体; 4. 再生骨 5.创造不会萎缩; 脂质合成代谢介质是 前生长因子表达。 原来的团队已经加入 埃默里脊柱中心的博登博士，参与了BMP在 灵长类动物的脊髓修复，以及内雷姆和古德伯格博士， 来自格鲁吉亚理工学院的生物工程师， 在人工室中生长并开发输送系统。 的 罗林斯学校的生物统计评估和社区外联 埃默里大学的公共卫生和杠杆资金的一个 经验丰富的风险投资集团也将被描述。 的 该提案的具体目标是建立一个研究小组， 以下1. 开发了一种定时释放的递送系统， 每隔一段时间释放细胞因子和生长因子， 骨再生 再生最初将在一个 室，然后在兔子，灵长类动物颌骨和脊柱中进行测试; 2. 骨 再生将在人类颌骨的临床试验中进行测试， 植入物放置和脊柱手术; 3. 社区外联 这些数据将由罗林斯公共卫生学院监测; 和4. 专业人士的技术教学将在 查佩尔山和UAB的牙科学校以及脊柱 埃默里大学中心。 与健康有关的问题是1。 为了能够快速增加颌骨中的骨，以放置 义齿、活动义齿和/或种植体，以及重建颌骨 癌症手术后骨丢失; 2. 为了快速重建骨骼， 脊柱; 3. 向医务和牙科人员传播信息， 社区，以及一般公众;和4。 利用 在经验丰富的风险投资集团的参与下进行融资。 P51 RR 00165 -36 1996年1月1日-1996年12月31日耶基斯区域灵长类动物研究 中心