Does Antipsychotic Dose Reduction Lead to Better Functional Recovery in First Episode Psychosis: A Randomised Controlled Trial

抗精神病药物剂量减少是否会导致首发精神病患者更好的功能恢复：一项随机对照试验

• 批准号: nhmrc : 1102394
• 负责人: A/Pr C. Barnaby Nelson
• 金额: $ 164.03万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-antipsychotic-dose-controlled-trial/662604
• 关键词: Does; Antipsychotic; Dose; Reduction; Lead

Can a person with a first episode of psychosis, once remitted, reduce their dosage of medication and still achieve better outcomes in functioning, physical health and brain volume, than if they had stayed on traditional maintenance doses of medication? This study will examine if using a dose reduction strategy in conjunction with an evidence based suite of psychosocial interventions leads to better social and vocational recovery and improved physical health and brain volume.

一个首次精神病发作的人，一旦缓解，减少他们的药物剂量，仍然可以在功能，身体健康和大脑容量方面取得更好的结果，而不是如果他们继续使用传统的维持剂量的药物？这项研究将检查是否使用剂量减少策略与一套基于证据的心理社会干预措施相结合，导致更好的社会和职业恢复，改善身体健康和脑容量。