NUCLEAR FAMILY COLLECTION FOR THE STUDY OF THE GENETICS OF ASTHMA

用于哮喘遗传学研究的核心家族收藏

• 批准号: 6278253
• 负责人: MALCOLM N BLUMENTHAL
• 金额: $ 3.69万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278253
• 关键词: asthma; clinical research; family genetics; human genetic material tag; human subject; questionnaires; respiratory function; serology /serodiagnosis

The overall objective of this investigation is to perform genetic studies of asthma. We will study 100 nuclear families whose members have asthma, including men, women and children 5 years and older of all ethnic backgrounds. All members of the families will be characterized using questionnaires, allergy skin testing, lung function studies, and blood studies for serum IgE levels, and genomic DNA. With this information we will identify and characterize the gene(s) and their products which are involved in the production of asthma. This information will further our understanding of asthma and provide new methods for its diagnosis and treatment.

这项调查的总体目标是进行基因研究 哮喘。 我们将研究 100 个成员患有哮喘的核心家庭， 包括所有种族的男性、女性和 5 岁及以上儿童 背景。 所有家庭成员都将使用以下特征进行表征 问卷调查、皮肤过敏测试、肺功能研究和血液检查 血清 IgE 水平和基因组 DNA 的研究。 有了这些信息我们 将识别和表征基因及其产物 参与哮喘的产生。 这些信息将进一步推动我们 了解哮喘并为其诊断和治疗提供新方法 治疗。