COMPARISON OF ANALGESICS IN POSTOPERATIVE ORTHOPEDIC SURGERY PATIENTS

骨科手术患者术后镇痛药的比较

• 批准号: 6279324
• 负责人: CLIFFORD W COLWELL
• 金额: $ 2.73万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279324
• 关键词: analgesics; clinical research; drug screening /evaluation; human subject; human therapy evaluation; nonsteroidal antiinflammatory agent; orthopedics; pain; postoperative state; questionnaires

This study compares two doses of a new COX-2 selective nonsteroidal anti-inflammatory drug, SC-58635, with a standard analgesic agent, propoxyphene napsylate, and with a placebo for the control of postoperative pain in patients hospitalized for procedures on the hip and knee. The primary end point is relief of pain which will be assessed using a standard questionnaire at frequent intervals for the first day and less often for up to five days.

本研究比较了新型 COX-2 选择性非甾体药物的两种剂量 抗炎药，SC-58635，与标准镇痛剂， 萘磺酸丙氧芬，以及用于控制的安慰剂 因髋关节手术住院的患者术后疼痛 和膝盖。 主要终点是缓解疼痛 定期使用标准调查问卷进行评估 第一天，频率较低，最多五天。