REGIONAL MYOCARDIAL FLOW MEASUREMENT BY XRAY COMPUTED TOMOGRAPHY

我们开发了一个数学模型，它包含了两个 造影剂中血管和EV传递的成分 媒体，描述为：C(T)=c*ta*[e(-t/b)+d*[e(-t/h)]，其中 C是对比浓度，t=时间，a、b和c是血管 伽玛变量拟合参数，d和h描述血管外 组织对比。在3头猪中，3个系列(每隔1.5分钟)20头 每隔一次心跳获得的顺序扫描是通过 电子束CT。在3个系列的第一个过程中，一剂 右房注射异丙咪醇(0.33cc/kg)2次以上， 4秒或8秒。该模型很好地拟合了采样密度值。 用于修饰或说明两个隔间的对比度处理。这一模式 心肌微循环指示剂的稀释过程可能非常 有助于量化在体心肌的功能 使用不同成像方法的微循环，如快速CT和 磁共振成像(使用合适的造影剂，如 螯合Gd)。

We have developed a mathematical model which incorporates two components accounting for both vascular and EV transit of contrast media, described by: C(t) = c * ta * [e(-t/b) + d * [e(-t/h)], where C is contrast concentration, t = time, a, b, and c are vascular gamma-variate fit parameters, and d and h describe extravascular tissue contrast. In 3 pigs, 3 series (at 1.5 min intervals) of 20 sequential scans, acquired every other heart beat, were obtained with electron beam CT. During the first of the series of 3, a bolus of iopamidol (0.33 cc/kg) was administered into the right atrium over 2, 4, or 8 sec. The model fitted well the sampled density values pertaining to contrast handling in both compartments. This model of the myocardial microcirculatory indicator dilution process may be very useful to quantify the function of the in vivo myocardial microcirculation using various imaging methods such as fast CT and magnetic resonance imaging (with a suitable contrast agent such as chelated gadolinium).