CT ANALYSIS OF MYOCARDIAL MICROCIRCULATORY FUNCTION

明年我们将继续使用电子束CT 用于估计心肌灌注和血容量的扫描仪。我们会 研究高胆固醇饮食十周后的猪，以便 模拟早期动脉粥样硬化。这样的喂养已经被证明是 在血管内皮功能改变和血管生成增加方面 所以我们希望能够检测到心肌微循环 通过改变的异质性和血液来量化这些变化 心肌灌注分布的流量-体积关系。 我们还将使用我们最近开发的双伽马变量模型 心肌声学造影剂分布评价微循环改变 通透性，也可能在动脉粥样硬化早期发生改变。

In the next year we'll continue to use the Electron Beam CT scanner to estimate myocardial perfusion and blood volume. We will study pigs after ten weeks of a diet high in cholesterol so as to simulate early atherosclerosis. Such feeding has been shown to result in altered endothelial function and increased angiogenesis of the myocardial microcirculation so we hope to be able to detect and quantitate these changes via the altered heterogeneity and blood flow-to-volume relationship of the myocardial perfusion distribution. We will also use our recently developed double gamma-variate model of myocardial contrast distribution to evaluate altered microcirculatory permeability, may also change in early atherosclerosis.