Meiotic recombination: how has this adaptive and evolutionary force been influenced by domestication and selective breeding?
减数分裂重组:这种适应性和进化力是如何受到驯化和选择性育种的影响的?
基本信息
- 批准号:NE/X011585/1
- 负责人:
- 金额:$ 9.99万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Plant domestication and the origin of agriculture date from ca. 10,000 years ago and have had profound effects on genome evolution demonstrated in the dramatic phenotypic differences between wild progenitors and domesticated crops. The transition from wild to domesticated plants followed by selective breeding has led to a reduction of genetic diversity. In this proposal we propose that meiotic recombination has played a key role in the reduction of genetic diversity in crops and the difference in genetic diversification between wild and crop species. Meiotic recombination is the basic process of sexual reproduction in germs cells that exchanges genetic information between chromosomes breaking the linkage between genes to form new allelic combinations. Meiotic recombination is a powerful force for plant genome evolution and adaptation to local environment as well as during breeding.Meiotic recombination and the intense selection during breeding have highly influenced plant genome evolution, but it remains unclear how these two processes are connected. In this project, we will evaluate how meiotic processes have diverged during breeding to effectively reduce genetic variation in crops. We will use advanced genomic technologies to sequence the DNA molecules bound to meiotic recombination proteins and profile the landscape of meiotic recombination genome-wide in wild and domesticated wheat. These new datasets will be unique due to their high-resolution and will allow us to explore local recombination rate over genes to test the genetic effects of domestication and to understand the differing evolutionary trajectories between natural and agricultural environments. This project will also address an essential knowledge gap as it will determine if genes of agricultural relevance that have been under strong selection during breeding have retained recombinational properties for further genetic improvements. Initial investigations will be carried out on trehalose phosphate synthase (TPS) and trehalose phosphate phosphatase (TPP). TPSs and TPPs determine the way sugars in plants are allocated which strongly affects plant adaptation to environment, growth and development and crop yields; they are important targets in crop improvement. With the knowledge generated in this project it will be possible to understand how some of the genetic variation in TPSs and TPPs has been lost during the crop selection process. We will also investigate local recombination rate over meiotic genes to test whether they too have been fixed by selective breeding. This will enable us to understand how loss of genetic diversity for important genes has reduced the adaptive potential to create novel genetic diversity. Overall, this project will generate high resolution and genome-wide recombination data to gain key insights in gene evolution between natural and agricultural environments. Our research initially focuses on three gene families but could be extended to any gene families in future studies. Hence, this project addresses a key fundamental question in evolutionary biology with the potential to establish new concepts on the genetic effects of domestication and to promote the strategic mission of NERC in "Population genetics and evolution".
植物驯化和农业的起源可追溯到公元前。它们对基因组进化产生了深远的影响,表现在野生祖先和驯化作物之间的巨大表型差异上。从野生植物到驯化植物的过渡以及随后的选择性育种导致了遗传多样性的减少。在这一提议中,我们提出,减数分裂重组在作物遗传多样性的减少以及野生和作物物种之间遗传多样性的差异中发挥了关键作用。减数分裂重组是生殖细胞有性生殖的基本过程,它在染色体之间交换遗传信息,打破基因之间的连锁,形成新的等位基因组合。减数分裂重组是植物基因组进化、适应环境和育种的重要动力,减数分裂重组和育种过程中的强烈选择对植物基因组进化有重要影响,但两者之间的联系尚不清楚。在这个项目中,我们将评估减数分裂过程如何在育种过程中分化,以有效地减少作物的遗传变异。我们将利用先进的基因组技术对与减数分裂重组蛋白结合的DNA分子进行测序,并对野生和驯化小麦的减数分裂重组全基因组进行分析。这些新的数据集将是独一无二的,因为它们的高分辨率,将使我们能够探索基因的局部重组率,以测试驯化的遗传效应,并了解自然和农业环境之间不同的进化轨迹。该项目还将解决一个重要的知识差距,因为它将确定在育种过程中经过强选择的农业相关基因是否保留了重组特性,以进一步进行遗传改良。对海藻糖磷酸合酶(TPS)和海藻糖磷酸磷酸酶(TPP)进行了初步研究。TPSs和TPPs决定了糖在植物中的分配方式,强烈影响植物对环境的适应、生长发育和作物产量;它们是作物改良的重要目标。利用本项目中产生的知识,将有可能了解TPS和TPP中的一些遗传变异是如何在作物选择过程中丢失的。我们还将调查减数分裂基因的局部重组率,以测试它们是否也被选择性育种所固定。这将使我们能够理解重要基因的遗传多样性丧失如何降低了创造新遗传多样性的适应潜力。总的来说,该项目将产生高分辨率和全基因组重组数据,以获得自然和农业环境之间基因进化的关键见解。我们的研究最初集中在三个基因家族,但在未来的研究中可以扩展到任何基因家族。因此,该项目解决了进化生物学中的一个关键的基本问题,有可能建立关于驯化的遗传效应的新概念,并促进NERC在“群体遗传学和进化”方面的战略使命。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christophe Lambing其他文献
Aggregation of chromosome axis proteins on the chromatin and in the nucleoplasm of Brassica oleracea meiocytes
甘蓝性母细胞染色质和核质中染色体轴蛋白的聚集
- DOI:
10.1016/j.cropd.2023.100038 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Wenbo Shan;Christophe Lambing - 通讯作者:
Christophe Lambing
Integrating genome editing with omics, artificial intelligence, and advanced farming technologies to increase crop productivity
将基因组编辑与组学、人工智能和先进的农业技术相结合,以提高作物生产力
- DOI:
10.1016/j.xplc.2025.101386 - 发表时间:
2025-07-14 - 期刊:
- 影响因子:11.600
- 作者:
Abigail Bradbury;Olivia Clapp;Anna-Sara Biacsi;Pallas Kuo;Oorbessy Gaju;Sadiye Hayta;Jian-Kang Zhu;Christophe Lambing - 通讯作者:
Christophe Lambing
1 REC 8-cohesin , chromatin and transcription orchestrate 1 meiotic recombination in the Arabidopsis genome 2 3
1 REC 8-粘连蛋白、染色质和转录协调 1 拟南芥基因组中的减数分裂重组 2 3
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Christophe Lambing;Andrew J. Tock;Kyuha Choi;Stephanie D. Topp;C. Pallas;Kuo;Alexander R Blackwell;Xiaohui Zhao;K. Osman;J. Higgins;C. Franklin;I. Henderson - 通讯作者:
I. Henderson
Epigenetic control of meiotic recombination in plants
- DOI:
10.1007/s11427-015-4811-x - 发表时间:
2015-02-04 - 期刊:
- 影响因子:9.500
- 作者:
Natasha Yelina;Patrick Diaz;Christophe Lambing;Ian R. Henderson - 通讯作者:
Ian R. Henderson
Christophe Lambing的其他文献
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{{ truncateString('Christophe Lambing', 18)}}的其他基金
Unravelling the meiotic single-cell transcriptomic atlas for the control of recombination.
揭示减数分裂单细胞转录组图谱以控制重组。
- 批准号:
BB/Y001591/1 - 财政年份:2024
- 资助金额:
$ 9.99万 - 项目类别:
Research Grant
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