GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
批准号:
6172945
负责人:
FREDIKA A ROBERTSON
金额:
$28.99万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-06-01 至 2002-03-31
关键词:
DNA damage chemical carcinogen chemical carcinogenesis enzyme activity enzyme induction /repression gene mutation human genetic material tag human tissue hydrogen peroxide hypoxanthine phosphoribosyltransferase inflammation keratinocyte nitric oxide nitric oxide synthase nitrites peroxidation peroxides polymerase chain reaction single strand conformation polymorphism skin neoplasms superoxides tissue /cell culture tumor suppressor genes
中文摘要
描述:此RO1的重点是诱导、修复和
O-和N-氧化剂对培养人DNA的致突变性
表皮角质形成细胞。推动这项研究的假设是没有
和过氧亚硝酸盐具有致突变性,可能是
人表皮角质形成细胞DNA氧化损伤和定点突变的研究
发炎的症状。
英文摘要
DESCRIPTION: The focus of this RO1 is on the induction, repair and
mutagenicity of O- and N- oxidant generated DNA damage in cultured human
epidermal keratinocytes. The hypothesis driving this research is that NO
and peroxynitrite are mutagenic, and could be important contributors to
oxidative DNA damage and mutation in human epidermal keratinocytes at sites
of inflammation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
NITRIC OXIDE AND TUMOR PROMOTION
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批准号:2462954
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项目类别:
-
资助金额:$25.83万
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财政年份:1997
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
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批准号:6376215
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项目类别:
-
资助金额:$29.67万
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财政年份:1997
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负责人:FREDIKA A ROBERTSON
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依托单位:
INFLAMMATION AND MULTISTAGE CARCINOGENESIS
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批准号:2733319
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项目类别:
-
资助金额:$28.09万
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财政年份:1997
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负责人:FREDIKA A ROBERTSON
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依托单位:
NITRIC OXIDE AND TUMOR PROMOTION
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批准号:2837792
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项目类别:
-
资助金额:$26.61万
-
财政年份:1997
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
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批准号:2683636
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项目类别:
-
资助金额:$25.64万
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财政年份:1997
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负责人:FREDIKA A ROBERTSON
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依托单位:
NITRIC OXIDE AND TUMOR PROMOTION
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批准号:6124460
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项目类别:
-
资助金额:$27.41万
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财政年份:1997
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
INFLAMMATION AND MULTISTAGE CARCINOGENESIS
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批准号:6172864
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项目类别:
-
资助金额:$35.48万
-
财政年份:1997
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
INFLAMMATION AND MULTISTAGE CARCINOGENESIS
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批准号:2405128
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项目类别:
-
资助金额:$27.9万
-
财政年份:1997
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
INFLAMMATION AND MULTISTAGE CARCINOGENESIS
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批准号:2895808
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项目类别:
-
资助金额:$33.61万
-
财政年份:1997
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
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批准号:2895481
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项目类别:
-
资助金额:$26.21万
-
财政年份:1997
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
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批准号:2009403
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项目类别:
-
资助金额:$26.48万
-
财政年份:1997
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负责人:FREDIKA A ROBERTSON
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依托单位:
CELLULAR BASIS FOR SILICONE-INDUCED IMMUNE RESPONSES
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批准号:2069786
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项目类别:
-
资助金额:$13.41万
-
财政年份:1993
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负责人:FREDIKA A ROBERTSON
-
依托单位:
CELLULAR BASIS FOR SILICONE-INDUCED IMMUNE RESPONSES
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批准号:3149511
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项目类别:
-
资助金额:$13.88万
-
财政年份:1993
-
负责人:FREDIKA A ROBERTSON
-
依托单位:
CELLULAR BASIS FOR SILICONE-INDUCED IMMUNE RESPONSES
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批准号:2069785
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项目类别:
-
资助金额:$12.9万
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财政年份:1993
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负责人:FREDIKA A ROBERTSON
-
依托单位:
ROLE OF ADHESION MOLECULES/CYTOKINES IN TUMOR PROMOTION
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批准号:3199676
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项目类别:
-
资助金额:$14.25万
-
财政年份:1991
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负责人:FREDIKA A ROBERTSON
-
依托单位:
ROLE OF ADHESION MOLECULES & CYTOKINES IN TUMOR PROMOTIO
-
批准号:3199675
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项目类别:
-
资助金额:$0.97万
-
财政年份:1991
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负责人:FREDIKA A ROBERTSON
-
依托单位:
ROLE OF ADHESION MOLECULES & CYTOKINES IN TUMOR PROMOTIO
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批准号:3199677
-
项目类别:
-
资助金额:$14.82万
-
财政年份:1991
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负责人:FREDIKA A ROBERTSON
-
依托单位:
ROLE OF ADHESION MOLECULES & CYTOKINES IN TUMOR PROMOTIO
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批准号:3199678
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项目类别:
-
资助金额:$13.71万
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财政年份:1991
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负责人:FREDIKA A ROBERTSON
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依托单位:
ROLE OF KERATINOCYTE SUB-POPULATIONS IN TUMOR PROMOTION
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批准号:3196176
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项目类别:
-
资助金额:$20.69万
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财政年份:1990
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负责人:FREDIKA A ROBERTSON
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依托单位:
ROLE OF KERATINOCYTE SUB-POPULATIONS IN TUMOR PROMOTION
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批准号:3196179
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项目类别:
-
资助金额:$18.06万
-
财政年份:1990
-
负责人:FREDIKA A ROBERTSON
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依托单位:
海外基金