DETECTION AND RISK OF EHRLICHIAL DISEASES

描述(改编自申请者摘要)：人粒细胞 埃立克体病(HGE)和人类单核细胞埃立克体病(HME)正在出现 壁虱传播的疾病在美国每年的发病率都是 不断增加，据报告有600多例人类埃立克体病 过去的十年里。这项研究的目的是检测存在和 HGE病原体及相关埃立克病原体在纽约的分布 州里。具体地说，申请者将评估犬类的效用 在流行地区评估HGE风险的血清学，2)测量犬类 在很少或没有HGE病例报告的地区的血清阳性率，3)检测 肩部硬蜱和美洲Amblyomma对埃立克体存在的影响 物种和相关病原体，以及4)建立犬血清库和 壁虱储存库，用于未来对新出现的壁虱传播的回顾性研究 该地区的疾病。

DESCRIPTION (adapted from applicant's abstract): Human granulocytic ehrlichiosis (HGE) and human monocytic ehrlichiosis (HME) are emerging tick-borne disease in the U.S. Annual incidence of both disease is increasing, with more than 600 cases of human ehrlichiosis reported in the last ten years. The purpose of this study is to detect the presence and distribution of the HGE agent and related ehrlichial pathogens in New York State. Specifically, the applicant will evaluate the utility of canine serology to assess risk for HGE in an endemic area, 2) measure canine seroprevalence in areas where few or no cases of HGE are reported, 3) test Ixodes scapularis and Amblyomma americanum for the presence of Ehrlichia species and related pathogens, and 4) establish a canine serum bank and a tick depository for future retrospective studies on emerging tick-borne diseases in the region.