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Crown ethers based photo take-apartable molecular hosts

基于冠醚的光可分解分子宿主

基本信息

批准号：
6316141
负责人：
ANDREI G KUTATELADZE
金额：
$ 13.52万
依托单位：
UNIVERSITY OF DENVER (COLORADO SEMINARY)
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-03-01 至 2004-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6316141
关键词：
adduct chemical synthesis chemosensitizing agent electron transport ethers molecular assembly /self assembly photochemistry

项目摘要

DESCRIPTION: (Applicant's Description) Basic and applied research targeting large molecular objects and supramolecular self-assembly in general has been on a steady rise over the past decade. Molecular engineering has reached a point where virtually any complicated shape of a molecular object can be manufactured and certain desired properties achieved. A systematic approach to constructing such objects includes identifying efficient bonding mechanisms designed to hold the construction blocks together and yet not frustrating the assembly step. Now as chemists are capable of assembling more and more complicated systems, it became evident to us that the time has come for the next logical step in molecular manipulations, that is, to develop intelligent ways and rules of molecular disassembly. This requires the search for and development of molecular buckles and latches that can be selectively unfastened on demand. One foreseeable application of these fasteners, which is particularly relevant to the field of photobiology, is their utilization in the rational design of molecular hosts capable of photoreversible accommodation of organic guests. In our preliminary studies we have identified a robust system based on dithiane-carbonyl adducts that satisfies all the criteria of molecular assembly and yet is capable of site-specific disassembly when irradiated in the presence of electron-transfer sensitizers. During the course of the proposed research rational design will be applied to develop a series of novel molecular hosts comprised of crown ethers and/or cryptand units linked via our photolabile tethers. The complexation selectivity and photochemistry/photophysics of the novel molecular systems will be examined to evaluate the prospects of their application in photobiology, e.g. as potential carriers for photodynamic therapies etc.

描述：（申请人的描述）基础和应用研究目标大分子物体和超分子自组装总体上已经过去十年稳步上升。分子工程已经达到了一个地步几乎可以制造任何复杂形状的分子物体以及达到的某些期望的特性。系统化的构建方法这些目标包括确定有效的粘合机制，旨在保持结构块组合在一起，但不会妨碍组装步骤。现在，随着化学家能够组装越来越复杂的系统，我们很明显，是时候采取下一个合乎逻辑的步骤了分子操作，即开发智能方法和规则分子分解。这就需要寻找和开发分子带扣和闩锁可根据需要选择性地解开。一这些紧固件的可预见应用，尤其与光生物学领域，是它们在合理设计中的应用能够光可逆容纳有机客体的分子宿主。在我们的初步研究中，我们已经确定了一个基于以下基础的强大系统：二噻烷-羰基加合物满足分子组装的所有标准但在存在辐射的情况下能够进行特定部位的分解电子转移敏化剂。在拟议的研究过程中，理性设计将应用于开发一系列由冠醚和/或组成的新型分子主体密码体单元通过我们的不耐光系绳连接。络合选择性并将检查新型分子系统的光化学/光物理学评估其在光生物学中的应用前景，例如作为光动力疗法等的潜在载体