CHARACTERIZATION OF NON-PROTEIN COLLOIDAL PLASMA VOLUME EXPANDERS

在截至1999年9月30日的报告年度内，该项目没有进行任何工作。我们目前正在探索使用Wyatt Technology， Corp.的多角度激光散射- se - hplc （mls - se - hplc）仪器测定Dextran 70、Dextran 40和Hetastarch样品的质量和数量平均分子量的可能性。该结果将允许将Wyatt值与我们之前分别使用静态激光散射和膜渗透法测定重量和数平均分子量的值进行比较，从而允许评估Wyatt设备/方法用于这些产品的商业表征的适用性。

During the reporting year ending September 30, 1999, no work was performed on this project. We are currently exploring the possiblity of having the weight and number average molecular weights determined for samples of Dextran 70, Dextran 40, and Hetastarch by Wyatt Technology, Corp. using their multi-angle laser light scattering-SE-HPLC (MALLS-SE-HPLC) apparatus. The results will permit a comparison of the Wyatt values with those that were determined by us previously using static laser light scattering and membrane osmometry for weight and number average molecular weights, respectively, thereby allowing an assessment of the appropriateness of the Wyatt apparatus/methodology for commercial characterization of these products.