CHARACTERIZATION OF NON-PROTEIN COLLOIDAL PLASMA VOLUME EXPANDERS

非蛋白质胶体血浆扩容剂的表征

• 批准号: 6293807
• 负责人: ANDREW F SHRAKE
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6293807
• 关键词: analytical chemistry; analytical method; blood /plasma substitute; blood groups; colloids; dextrans; drug quality /standard; high performance liquid chromatography; molecular weight; plasma

During the reporting year ending September 30, 1999, no work was performed on this project. We are currently exploring the possiblity of having the weight and number average molecular weights determined for samples of Dextran 70, Dextran 40, and Hetastarch by Wyatt Technology, Corp. using their multi-angle laser light scattering-SE-HPLC (MALLS-SE-HPLC) apparatus. The results will permit a comparison of the Wyatt values with those that were determined by us previously using static laser light scattering and membrane osmometry for weight and number average molecular weights, respectively, thereby allowing an assessment of the appropriateness of the Wyatt apparatus/methodology for commercial characterization of these products.

在截至 1999 年 9 月 30 日的报告年度内，该项目没有开展任何工作。 我们目前正在探索 Wyatt Technology, Corp. 使用其多角度激光光散射-SE-HPLC (MALLS-SE-HPLC) 设备测定右旋糖酐 70、右旋糖酐 40 和 Hetastarch 样品的重均分子量和数均分子量的可能性。 结果将允许将 Wyatt 值与我们之前使用静态激光散射和膜渗透压测定法分别测定重均分子量和数均分子量的值进行比较，从而可以评估 Wyatt 装置/方法对这些产品的商业表征的适当性。