Biomarkers of Oxidative Stress Study
氧化应激研究的生物标志物
基本信息
- 批准号:6227942
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Antioxidants in the blood plasma of rats were measured as part of a comprehensive, multilaboratory validation study searching for non- invasive biomarkers of oxidative stress. For this initial study an animal model of CCl4 poisoning was studied. The time-(2, 7 and 16 h) and dose-(120 mg/kg and 1200 mg/kg, i. p.) dependent effects of CCl4 on plasma levels of alpha-tocopherol, ascorbic acid, glutathione (GSH and GSSG), uric acid and total antioxidant capacity were investigated to determine whether the oxidative effects of CCl4 would result in losses of antioxidants from plasma. The alpha-tocopherol concentration was decreased in CCl4-treated rats. However, due to concomitant decreases in cholesterol and triglycerides, it was impossible to dissociate oxidation of alpha-tocopherol from generalized lipid changes. Ascorbic acid levels were higher with treatment at the earliest time point; the ratio of GSH to GSSG generally declined, and uric acid remained unchanged. Total antioxidant capacity showed no significant change except for 16 h after the high dose, when it was increased. These results suggest that plasma changes due to liver malfunction and rupture of liver cells impede detection of any potential changes in the antioxidant status of the plasma. - biomarkers, oxidative damage, carbon tetrachloride
测量大鼠血浆中的抗氧化剂,作为寻找氧化应激的非侵入性生物标志物的综合性多实验室验证研究的一部分。在这项初步研究中,研究了四氯化碳中毒的动物模型。时间(2、7和16 h)和剂量(120 mg/kg和1200 mg/kg,i.第页)研究了CCl 4对α-生育酚、抗坏血酸、谷胱甘肽(GSH和GSSG)、尿酸和总抗氧化能力的血浆水平的依赖性影响,以确定CCl 4的氧化作用是否会导致血浆中抗氧化剂的损失。CCl 4处理大鼠的α-生育酚浓度降低。然而,由于胆固醇和甘油三酯同时降低,无法将α-生育酚氧化与全身脂质变化分离。在最早的时间点,抗坏血酸水平较高,GSH与GSSG的比值普遍下降,尿酸保持不变。总抗氧化能力没有显着的变化,除了16小时后,高剂量,当它增加。这些结果表明,由于肝功能障碍和肝细胞破裂导致的血浆变化阻碍了血浆抗氧化状态的任何潜在变化的检测。- 生物标志物,氧化损伤,四氯化碳
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RONALD P MASON其他文献
RONALD P MASON的其他文献
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{{ truncateString('RONALD P MASON', 18)}}的其他基金
CHARACTERIZATION OF RAT HEMOGLOBIN THIYL RADICALS BY W BAND
通过 W 波段表征大鼠血红蛋白硫酰基自由基
- 批准号:
6120646 - 财政年份:1998
- 资助金额:
-- - 项目类别:
CHARACTERIZATION OF RAT HEMOGLOBIN THIYL RADICALS BY W BAND
通过 W 波段表征大鼠血红蛋白硫酰基自由基
- 批准号:
6251759 - 财政年份:1997
- 资助金额:
-- - 项目类别:
DETECT AND CHARACTERIZE FREE RADICAL METABOLITES OF HYDRAZINE BASED DRUGS
检测并表征肼基药物的自由基代谢物
- 批准号:
6254253 - 财政年份:1997
- 资助金额:
-- - 项目类别:
NITRIC OXIDE AND THE METABOLISM OF TOXIC CHEMICALS AND DRUGS
一氧化氮与有毒化学品和药物的代谢
- 批准号:
6106716 - 财政年份:
- 资助金额:
-- - 项目类别:
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