Brain SPECT Imaging with Improved Resolution

描述（由申请人提供）：核成像（SPECT和PET）是 最常用于功能性脑成像的模态。然而一个主要 神经SPECT成像的局限性是空间分辨率。脑成像 由于复杂的结构， 所涉及的范围和定量绘图所需的准确性。系统误差 由于患者运动和探测器的机械未对准 导致空间分辨率降低，并可能产生妨碍 诊断.由于长时间采集，患者运动是一个重要问题 时间（20 - 30分钟），尤其是儿科患者和 患有神经系统疾病我们在之前的工作中已经表明，我们的小说 该技术能够感知患者运动并确定探测器 不对准非常高的精度，空间分辨率是 通过3D图像重建可恢复。在第一阶段，我们将展示 我们的方法的临床可行性，通过生产的原型， 硬件和测试的概念对人类受试者在SPECT扫描仪。这 研究将导致一个独立的商业产品，可以利用与 几乎任何SPECT成像系统。 拟定商业应用： 我们预计，这一发展项目将导致一个独立的商业 通过提高空间分辨率增强脑SPECT成像的产品， 消除图像中的伪影。该产品将兼容几乎所有 SPECT扫描仪，为该产品创造了相当大的市场。我们的愿景是 通过进一步研究先进的图像处理和重建， 该产品将发展成为一种专门的定量神经SPECT分析 包.这项研究还可能作为相机技术找到商业用途 验收测试和质量保证。

DESCRIPTION (Provided by Applicant): Nuclear imaging (SPECT and PET) is the most commonly used modality for functional brain imaging. However, a major limitation of neurological SPECT imaging is spatial resolution. Brain imaging requires optimal spatial resolution because of the intricate structures involved and the accuracy needed for quantitative mapping. Systematic errors from both patient motion and mechanical misalignment of the detectors contribute to lost spatial resolution and could produce artifacts that hinder diagnosis. Patient motion is a significant issue due to the long acquisition times (20 to 30 minutes), especially for pediatric patients and for patients with neurological disorders. We have shown in our prior work that our novel technique has the ability to sense patient motion and determine detector misalignment to very high accuracy, and that the spatial resolution is recoverable through 3D image reconstruction. In Phase I, we will demonstrate the clinical feasibility of our approach by producing prototypes of the hardware and testing the concept on human subjects in a SPECT scanner. This research will lead to a standalone commercial product that can be utilized with virtually any SPECT imaging system. PROPOSED COMMERCIAL APPLICATION: We expect that this development project will lead to a standalone commercial product to augment brain SPECT imaging by improving spatial resolution and eliminating artifacts in images. The product will be compatible with virtually all SPECT scanners, creating a sizable market for the product. Our vision is that through further research in advanced image processing and reconstruction, the product will evolve into a specialized quantitative neurological SPECT analysis package. This research may also find commercial use as a technique for camera acceptance testing and quality assurance.