NANO-HYDROXYAPATITE SCAFFOLDS TO FILL PERIODONTAL VOIDS

这项拨款申请的整体目标是聘用 纳米粒子技术提高生物聚合物支架的能力 支持牙槽骨重建种植体作为同期使用的固位体 骨移植就会发生。调查人员的假设是 纳米羟基磷灰石将在力学和生物活性方面都有所改善 接枝材料的性能。在本申请中，调查人员将 两种纳米材料制备羟基磷灰石负载聚酯泡沫填料 适合体外和体内使用的羟基磷灰石或微米级羟基磷灰石 活体评价。然后，他们将进行体外机械测试 微米级和纳米级羟基磷灰石抗压强度的建立 在整个骨愈合过程中保持牙槽骨的完整性。最后， 他们将在啮齿动物牙周缺陷模型中进行筛查研究，以 对宏观和纳米泡沫结构的骨整合进行量化 羟基磷灰石在整个牙槽骨中保持牙槽骨完整性 骨愈合期。 建议的商业应用： 骨是人体内仅次于血液的第二大植入材料。美国每年进行的骨移植手术超过45万例(全球为220万例)。这些植入物的市场潜力为4亿至6亿美元。新的组织工程骨替代材料，包括那些应用于牙周应用的材料，将在这个不断增长的市场中找到一席之地。

The overall objective of this grant application is to employ nanoparticle technology to improve the ability of biopolymeric scaffolds to support ridge reconstruction implants as consolidation of concurrently used bone grafts occurs. The hypothesis of the investigators is that nano-hydroxyapatite will improve upon both the mechanical and bioactivity properties of the graft material. In this application the investigators will prepare hydroxyapatite loaded polyester foam fillers with either nano hydroxyapatite or micron-sized hydroxyapatite suitable for both in vitro and in vivo evaluation. They will then conduct in vitro mechanical testing of the compressive strength of the micron and nano hydroxyapatite to establish maintenance of ridge integrity throughout the period of bone healing. Finally, they will conduct a screening study in a rodent periodontal defect model to quantify the osteointegration of foam constructs made with macro and nano hydroxyapatite to establish maintenance of ridge integrity throughout the period of bone healing. PROPOSED COMMERCIAL APPLICATION: Bone is the second most implanted material in the body after blood. There are more than 450,000 bone graft procedures performed annually in the U.S. (2.2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in this ever-growing market.