NANO-HYDROXYAPATITE SCAFFOLDS TO FILL PERIODONTAL VOIDS

纳米羟基磷灰石支架填充牙周空隙

• 批准号: 6337587
• 负责人: DEBRA J TRANTOLO
• 金额: $ 10万
• 依托单位: CAMBRIDGE SCIENTIFIC, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-07 至 2002-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337587
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; bone regeneration; bone transplantation; histology; hydroxyapatites; nanotechnology; periodontium disorder; tissue engineering; tissue support frame

The overall objective of this grant application is to employ nanoparticle technology to improve the ability of biopolymeric scaffolds to support ridge reconstruction implants as consolidation of concurrently used bone grafts occurs. The hypothesis of the investigators is that nano-hydroxyapatite will improve upon both the mechanical and bioactivity properties of the graft material. In this application the investigators will prepare hydroxyapatite loaded polyester foam fillers with either nano hydroxyapatite or micron-sized hydroxyapatite suitable for both in vitro and in vivo evaluation. They will then conduct in vitro mechanical testing of the compressive strength of the micron and nano hydroxyapatite to establish maintenance of ridge integrity throughout the period of bone healing. Finally, they will conduct a screening study in a rodent periodontal defect model to quantify the osteointegration of foam constructs made with macro and nano hydroxyapatite to establish maintenance of ridge integrity throughout the period of bone healing. PROPOSED COMMERCIAL APPLICATION: Bone is the second most implanted material in the body after blood. There are more than 450,000 bone graft procedures performed annually in the U.S. (2.2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in this ever-growing market.

本补助金申请的总体目标是雇用