NANO-HYDROXYAPATITE SCAFFOLDS TO FILL PERIODONTAL VOIDS

这项拨款申请的总体目标是雇用 纳米颗粒技术，以提高生物聚合物支架的能力， 支持嵴重建植入物作为合并使用 进行骨移植。调查人员的假设是， 纳米羟基磷灰石将改善力学性能和生物活性 移植物材料的特性。在本申请中，研究人员将 制备羟基磷灰石负载的聚酯泡沫填料， 羟基磷灰石或微米级羟基磷灰石适合于体外和体内 体内评价然后，他们将进行体外机械测试， 抗压强度的微米和纳米羟基磷灰石建立 在整个骨愈合期间保持牙槽嵴的完整性。最后， 他们将在啮齿动物牙周缺损模型中进行筛选研究， 量化由宏观和纳米材料制成的泡沫结构的骨整合 羟基磷灰石，以建立整个牙槽嵴完整性的维护 骨愈合期。 拟定商业应用： 骨是仅次于血液的第二大植入材料。美国每年进行超过45万例骨移植手术（全球220万例）。这些植入物的市场潜力为4亿至6亿美元。新的组织工程骨替代材料，包括那些适用于牙周应用，将在这个不断增长的市场找到一个利基。

The overall objective of this grant application is to employ nanoparticle technology to improve the ability of biopolymeric scaffolds to support ridge reconstruction implants as consolidation of concurrently used bone grafts occurs. The hypothesis of the investigators is that nano-hydroxyapatite will improve upon both the mechanical and bioactivity properties of the graft material. In this application the investigators will prepare hydroxyapatite loaded polyester foam fillers with either nano hydroxyapatite or micron-sized hydroxyapatite suitable for both in vitro and in vivo evaluation. They will then conduct in vitro mechanical testing of the compressive strength of the micron and nano hydroxyapatite to establish maintenance of ridge integrity throughout the period of bone healing. Finally, they will conduct a screening study in a rodent periodontal defect model to quantify the osteointegration of foam constructs made with macro and nano hydroxyapatite to establish maintenance of ridge integrity throughout the period of bone healing. PROPOSED COMMERCIAL APPLICATION: Bone is the second most implanted material in the body after blood. There are more than 450,000 bone graft procedures performed annually in the U.S. (2.2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in this ever-growing market.