Biodegradable Scaffolds for Periodontal Void-Filling

描述：在牙周牙槽骨重建和随后种植中 在固定方面，挑战是用一种移植材料来填充骨洞，这将 保持移植区域的体积和形状，并支撑结构 在新骨再生过程中保持整个部位的完整性。这个 这项资助申请的目标是使用生物聚合物支架来 改善自体骨的成型、操作和力学性能 通过增强其骨诱导性和保持牙槽骨形状和 重建后的体积。尽管自体移植是骨的黄金标准 牙周牙槽突自体骨移植修复效果观察 重建有时是不可预测的，失去了重建的高度 而且，成交量并不少见。应用程序假定使用 可降解的生物聚合物支架将至少实质性地延长自体移植物 而不会影响其骨诱导性能，充其量可改善 作为接枝材料的接枝材料的力学和生物活性 合并就会发生。因此，这个第一阶段的项目将调查 增强组织反应的可行性，并保持机械 牙周缺损处的完整性，需用牙周修复或空洞充填 利用体外机械和体内组织学方法构建生物聚合物支架 和组织形态计量学结果。 建议的商业应用： 骨是人体内仅次于血液的第二大植入材料。有更多的 美国每年进行45万例骨移植手术(全球220万例)。 这些植入物的市场潜力为4亿至6亿美元。新型组织工程学 骨替代材料，包括那些应用于牙周应用的材料，将 在不断增长的市场中找到一个利基市场。

DESCRIPTION: In periodontal ridge reconstruction and subsequent implant fixation, the challenge is to fill bony voids with a graft material, which will maintain the volume and shape of the grafted area and support the structural integrity of the site throughout the course of new bone regeneration. The objective of this grant application is to employ biopolymer scaffolds to improve upon the molding, handling, and mechanical properties of autograft bone by augmenting its osteoinductivity and ability to maintain ridge shape and volume after reconstruction. Although autograft is the gold standard of bone transplantation, the results of autograft reconstruction in periodontal ridge reconstruction are sometimes unpredictable and loss of reconstructive height and volume is not infrequent. The application posits that the use of a degradable biopolymeric scaffold will at least materially extend an autograft without compromising its osteoinductive properties and at best improve upon both the mechanical and bioactivity properties of the graft material as graft consolidation occurs. Therefore, this Phase I project will investigate the feasibility of enhancing tissue responses in, and maintaining the mechanical integrity of, periodontal defects subject to repair or void filling using a biopolymeric scaffold by employing in vitro mechanical and in vivo histologic and histomorphometric outcomes. PROPOSED COMMERCIAL APPLICATION: Bone is the second most implanted material in the body after blood. There are more than 450,000 bone graft procedures proformed annually in the U.S. (2.2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in the ever-growing market.