UV and Ozone Plasma Decontamination with Ultrasound

描述（由申请人提供）：拟议项目的目的是 为了开发一种改进的人类血浆净化技术， 这是稻草色的液体， 组件已被删除。富含凝血蛋白和免疫因子， 血浆用于严重出血患者的直接输血， 生产超过100种独立的药物成分血浆， 然而，它也富含营养，因此经常窝藏传染性病原体， 特别是病毒如HIV和各种肝炎病毒株。 降低通过血浆或其浓缩物传播疾病的风险 因此，开发了几种去污技术。 不幸的是，这些技术往往是昂贵的，无法治疗 无包膜病毒，需要汇集数千个血浆单位， 严重破坏血浆蛋白质或留下一些残留的有毒化学物质 添加剂 提出的技术创新是利用超声波来改善 两种传统技术的性能，紫外线曝光和臭氧 治疗因为这两种技术都非常有效 他们各自的能力结合起来，应该会产生一种相当安全的产品。的 将超声波添加到该组合中的期望益处包括更便宜 操作，提高处理速度和更大的效率。 拟定商业应用： 等离子体和等离子体产品已经构成了数十亿美元的产业。 商业 这项研究的潜力是为这个行业提供一个新的，更有效，更便宜的 净化血浆的技术。 出售的产品包括一个自动化处理器 和独特的一次性用品

DESCRIPTION (Provided from Applicant): The purpose of the proposed project is to develop an improved technology for the decontamination of human plasma, which is the straw-colored liquid that remains after all of the cellular components have been removed. Rich in clotting proteins and immune factors, plasma is used for direct transfusion for patients with severe bleeding and for the manufacture of more than 100 separate pharmaceutical components Plasma is also rich in nutrients, however, and thus often harbors infectious pathogens, notably viruses such as HIV and the various strains of hepatitis. To reduce the risk of spreading diseases through plasma or its concentrated components, several decontamination techniques have therefore been developed. Unfortunately, these techniques are often expensive, unable to treat non-enveloped viruses, require the pooling of thousands of plasma units, severely damage the plasma proteins or leave some residual toxic chemical additives. The proposed technological innovation is to use ultrasound to improve the performance of two conventional technologies, UV light exposure and ozone treatment. Because both of these techniques are known to be quite effective individually, their combined abilities should yield a quite safe product. The desired benefits of adding ultrasound to this combination include cheaper operation, improved processing speed and greater effectiveness. PROPOSED COMMERCIAL APPLICATION: Plasma and plasma products already comprise a multi-billion dollar industry. The commercial potential of this research is to provide this industry with a new, more effective and cheaper technique to decontaminate plasma. The products to be sold include an automated processor and its unique disposables.