UV and Ozone Plasma Decontamination with Ultrasound

超声波紫外线和臭氧等离子净化

• 批准号: 6503365
• 负责人: HOWARD E PURDUM
• 金额: $ 7.54万
• 依托单位: CRYOFACETS, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6503365
• 关键词: antisepsis; antiseptic sterilization; blood bank /supply contamination; blood proteins; communicable disease control; fibrinogen; immunoglobulins; ozone; plasma; technology /technique development; ultrasound; ultraviolet radiation; virus; von Willebrand factor

DESCRIPTION (Provided from Applicant): The purpose of the proposed project is to develop an improved technology for the decontamination of human plasma, which is the straw-colored liquid that remains after all of the cellular components have been removed. Rich in clotting proteins and immune factors, plasma is used for direct transfusion for patients with severe bleeding and for the manufacture of more than 100 separate pharmaceutical components Plasma is also rich in nutrients, however, and thus often harbors infectious pathogens, notably viruses such as HIV and the various strains of hepatitis. To reduce the risk of spreading diseases through plasma or its concentrated components, several decontamination techniques have therefore been developed. Unfortunately, these techniques are often expensive, unable to treat non-enveloped viruses, require the pooling of thousands of plasma units, severely damage the plasma proteins or leave some residual toxic chemical additives. The proposed technological innovation is to use ultrasound to improve the performance of two conventional technologies, UV light exposure and ozone treatment. Because both of these techniques are known to be quite effective individually, their combined abilities should yield a quite safe product. The desired benefits of adding ultrasound to this combination include cheaper operation, improved processing speed and greater effectiveness. PROPOSED COMMERCIAL APPLICATION: Plasma and plasma products already comprise a multi-billion dollar industry. The commercial potential of this research is to provide this industry with a new, more effective and cheaper technique to decontaminate plasma. The products to be sold include an automated processor and its unique disposables.

描述(由申请人提供)：建议项目的目的是 为了开发一种用于净化人体血浆的改进技术， 这是一种稻草色的液体，在所有细胞 组件已被移除。富含凝血蛋白和免疫因子， 血浆用于严重出血患者的直接输血，并用于 制造100多种不同的药物成分，等离子体是 然而，它们也富含营养，因此经常藏有传染性病原体， 尤其是艾滋病毒和各种肝炎病毒。 降低通过血浆或其浓缩物传播疾病的风险 因此，已经开发了几种去污技术。 不幸的是，这些技术往往很昂贵，无法治疗 无包膜病毒，需要汇集数千个血浆单位， 严重破坏血浆蛋白质或残留一些有毒化学物质 添加剂。 提出的技术创新是利用超声波来提高 紫外线照射和臭氧两种传统技术的性能 治疗。因为众所周知，这两种技术都非常有效。 就个人而言，他们的综合能力应该会产生一个相当安全的产品。这个 在这种组合中加入超声波的预期好处包括更便宜 操作，提高了处理速度和更大的效果。 建议的商业应用： 等离子和等离子产品已经构成了一个价值数十亿美元的产业。商业广告 这项研究的潜力在于为该行业提供一种新的、更有效和更便宜的 净化血浆的技术。即将出售的产品包括一台自动处理器 及其独一无二的一次性用品。