SURGICAL ADHESIVE FOR JOINING AND HEALING MOIST TISSUE

描述(逐字摘自申请人的摘要)：开发 用于密封或连接湿组织的生物基外科粘合剂 建议。这种材料将克服粘合强度低的问题 由目前可用的明胶和纤维蛋白外科粘合剂展示。这个 粘合剂在湿界面、活性部位尤其有效。 出血或处于高压或高压区域。关键的创新是使用 对生物安全的蛋白质进行了修饰，包括 高粘附性多酚官能团，将表面流体从 并在粘合剂固化过程中与组织形成强烈的共价键。 这些官能团负责在高强度水中的粘合 由贻贝等海洋生物生产的耐腐蚀的蛋白胶。同相 I、粘合剂将由多酚功能化蛋白通过 交联形成粘附性水凝胶及其作为组织粘合剂的效果 在体外作为成分参数的函数进行评估。粘合剂 将与商用明胶和纤维蛋白粘合剂进行比较。在第二阶段， 通过胶粘剂的优化进一步开发外科用胶粘剂 以及弹性体性能和生物降解性的评价， 几种生物材料的生物相容性、粘接寿命和毒性 组织类型。 建议的商业应用： 该商业产品是一种内用外科胶粘剂。粘合剂应该是两个- 用于组织封闭或连接的各种外科手术中的部分制剂 是我们所需要的。EIC实验室将通过获得粘合剂技术的许可来寻求收入。

DESCRIPTION (Verbatim from the Applicant's Abstract): The development of a biologically based surgical adhesive for sealing or joining wet tissue is proposed. The material will overcome the problems of low-strength adhesion exhibited by currently available gelatin and fibrin surgical adhesives. The adhesive will be particularly effective at wet interfaces, at sites of active bleeding or in areas of high tension or pressure. The key innovation is the use of biologically safe proteins that have been modified to include highly-adhesive polyphenolic functional groups that displace surface fluid from wet tissue and form strong covalent bonds to the tissue during adhesive curing. These functional groups are responsible for adhesion in the high-strength water resistant protein glue produced by marine organisms such as mussels. In Phase I, adhesives will be prepared from polyphenol functionalized proteins through cross linking to form adhesive hydrogels and their efficacy as tissue adhesives evaluated in vitro as a function of compositional parameters. The adhesives will be compared with commercial gelatin and fibrin adhesives. In Phase II, surgical adhesive would be further developed through optimization of adhesive and elastomeric properties and evaluation of biodegradability, biocompatibility, longevity of adhesive bond and toxicity in several in vivo tissue types. PROPOSED COMMERCIAL APPLICATION: The commercial product is a surgical adhesive for internal use. The adhesive would be a two- part formulation for use in a variety of surgical procedures where sealing or joining of tissue is desired. EIC Laboratories would seek revenue through the licensing of adhesive technology.