INSULIN & PULSATILITY

本研究的总体假设是：老年人（60- 80岁）的胰岛素脉冲曲线与年轻人（20-30岁）的胰岛素脉冲曲线不同。更具体的假设是：1）与老年人相比，年轻人的脉搏曲线将具有更大的脉搏幅度; 2）年轻和老年受试者的脉搏曲线将具有相似的脉搏频率; 3）老年人的脉冲间胰岛素分泌将升高，以及4）胰岛素脉冲幅度和胰岛素敏感性之间将存在显著的负相关性。很明显，当激素以脉冲方式（生理方式）到达靶组织时，会刺激更大的生物反应。我们将记录老年人胰岛素抵抗增加的部分原因是否部分是由于胰岛素脉冲谱的改变。

The overall hypothesis of this study is: the pulse profile of insulin for old persons (60-80yrs) will be different when compared to that of young persons(20-30 yrs). The more specific hypotheses are 1)pulse profiles for young persons will have a larger pulse amplitude when compared to that of old persons; 2)pulse profiles for young and old subjects will have similar pulse frequencies; 3)interpulse insulin secretion will be elevated in older persons and 4)a significant negative correlation will exist between insulin pulse amplitude and insulin sensitivity. It is clear that hormones stimulate greater biological responses when they reach the target tissue in a pulsatile manner (the physiological manner). We will document whether part of the cause for increased insulin resistance in older persons is partially due to an altered insulin pulse profile.