INSULIN & PULSATILITY

这项研究的总体假设是：与年轻人(20-30岁)相比，老年人(60-80岁)的胰岛素脉搏曲线将有所不同。更具体的假设是：1)与老年人相比，年轻人的脉搏波幅度更大；2)年轻人和老年人的脉搏波频率相似；3)老年人脉间胰岛素分泌增加；4)胰岛素脉搏幅度与胰岛素敏感性呈显著负相关。很明显，当荷尔蒙以脉动方式(生理方式)到达目标组织时，它们会刺激更大的生物反应。我们将记录老年人胰岛素抵抗增加的部分原因是否部分是由于胰岛素脉搏曲线的改变。

The overall hypothesis of this study is: the pulse profile of insulin for old persons (60-80yrs) will be different when compared to that of young persons(20-30 yrs). The more specific hypotheses are 1)pulse profiles for young persons will have a larger pulse amplitude when compared to that of old persons; 2)pulse profiles for young and old subjects will have similar pulse frequencies; 3)interpulse insulin secretion will be elevated in older persons and 4)a significant negative correlation will exist between insulin pulse amplitude and insulin sensitivity. It is clear that hormones stimulate greater biological responses when they reach the target tissue in a pulsatile manner (the physiological manner). We will document whether part of the cause for increased insulin resistance in older persons is partially due to an altered insulin pulse profile.