RESEARCH TRAINING IN PHYSIOLOGICAL ADAPTATIONS TO STRESS

压力生理适应研究培训

• 批准号: 2654890
• 负责人: PETER A FARRELL
• 金额: $ 7.76万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2654890
• 关键词: RESEARCH; TRAINING; PHYSIOLOGICAL; ADAPTATIONS; STRESS

Physiological adaptations to stress encompass a wide range of responses from alterations of molecular structure affecting cellular metabolism to organismal remodeling. Adaptations may be positive, such as those brought about by increased participation in regular physical activity, or they may have pathological sequelae, e.g. disordered inflammatory responses leading to rheumatoid arthritis, or skeletal muscle and islet Beta-cell pathologies engendered by obesity. This proposal describes a course of training in physiology with a specific focus on adaptations to stress. We propose a pre-doctoral training program that will take advantage of the existing, internationally recognized strengths of faculty located at the College of Medicine in Hershey and at the Noll Physiological Research Center (and other units) at the University Park campus of The Pennsylvania State University. The goal of the proposed training program is to produce scientists with the ability to generate, integrate, and apply information gathered by multiple approaches to the study of physiology. The training program will be housed in the Intercollege Graduate Program in Physiology which has a thirty-year history of graduate student education. Faculty of the training program are committed to enhancing diversity with minority recruitment and to promoting ethics in research. The training program seeks support for 6 predoctoral trainees per year whose proficiency to integrate information gathered at all levels of inquiry will be developed by a rigorous curriculum, structured research experiences and dedicated mentorship by program preceptors. Students will integrate knowledge (rather than simply gaining technological proficiency) gained through laboratory rotations with preceptors whose research programs span a broad range of inquiry. The Stress Physiology Seminar Series will involve renowned speakers who investigate physiological adaptations to stress from diverse perspectives. After the formal presentations, trainees will interact as a group with each speaker. A core course, required of all of trainees and delivered via state-of-the-art telecommunications, will emphasize physiological mechanisms for maintaining homeostasis under acute and/or chronic stress conditions. The preceptors have been selected because of their research focus on stress and the strengths of their individual and combined research programs. A rich academic environment is provided at both campuses with strong research support and institutional commitment. The Pennsylvania State University will provide four new full assistantships if this application is funded. Students who complete their training through this program will not only have a thorough knowledge of lab techniques ranging from molecular to whole organism, but the capacity to understand and synthesize complex information resulting from research examining the physiological (molecular, metabolic, and systemic ) adaptations to stress.

对压力的生理适应包括广泛的反应 从影响细胞代谢的分子结构改变， 器官重塑适应可能是积极的，例如 通过增加定期体育活动的参与，或者他们 可能有病理学后遗症，例如炎症反应紊乱 导致类风湿性关节炎，或骨骼肌和胰岛β细胞 由肥胖引起的疾病。该提案描述了一个过程， 生理学培训，特别侧重于适应压力。 我们提出了一个博士前培训计划，将利用 现有的，国际公认的师资力量位于 赫尔希医学院和诺尔生理研究所 中心（和其他单位）在大学公园校园 宾夕法尼亚州立大学。拟议培训计划的目标 是培养有能力产生，整合， 将通过多种途径收集的信息应用于研究 physiology.该培训计划将设在国际学院 生理学研究生课程有三十年的历史， 研究生教育。学院的培训计划是致力于 通过招聘少数族裔来加强多样性， 在研究中。该培训计划寻求支持6博士预科 每年接受培训的学员中， 所有层次的探究都将通过严格的课程来发展， 结构化的研究经验和专门的导师计划 导师学生将整合知识（而不是简单地获得 技术熟练程度）， 其研究项目涵盖广泛的研究领域的导师。的 压力生理学研讨会系列将涉及著名的发言人， 研究对来自不同环境的压力的生理适应 视角在正式的演讲之后，学员们将进行互动， 每个演讲者都有一个小组。核心课程，所有学员都必须参加， 通过最先进的电信传输，将强调 用于在急性和/或慢性炎症条件下维持体内平衡的生理机制 慢性应激状态导师被选中是因为 他们的研究集中在压力和他们个人的优势， 联合研究计划。提供丰富的学术环境， 两个校区都有强大的研究支持和机构承诺。 宾夕法尼亚州立大学将提供四个新的完整的 如果这个应用程序是资助。完成学业的学生 通过该计划的培训将不仅有一个全面的知识， 从分子到整个生物体的实验室技术， 理解和综合研究产生的复杂信息 检查生理（分子，代谢和系统） 适应压力。