GROWTH HORMONE VARIANTS, PULSATILITY & RESISTANT EXERCISE

生长激素变体，脉动

• 批准号: 6265945
• 负责人: WILLIAM KRAEMER
• 金额: $ 3.26万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265945
• 关键词: exercise; hormone biosynthesis; human subject; somatotropin

The aim of this study is to determine the impact of resistance training on growth hormone (GH) concentrations, pulse characteristics of GH secretion and GH actions on target tissue. Serial blood sampling over 16 hours will be performed to measure GH concentrations under normal conditions and high volume heavy resistance exercise. It is hypothesized that GH will increase in response to the exercise dose, due to an increase in width and amplitude of GH pulses. GH immunoreactivity is expected to show an exercise -dose relationship where the greatest response is expected in the lower molecular weight range. It is also expected that there is an exercise-dose relationship on the proliferation of myotubes.

本研究的目的是确定阻力训练对生长激素 (GH) 浓度、GH 分泌的脉冲特征以及 GH 对靶组织的作用的影响。 将进行超过 16 小时的连续血液采样，以测量正常条件和高强度抗阻运动下的 GH 浓度。 据推测，由于 GH 脉冲的宽度和幅度增加，GH 会响应运动剂量而增加。 GH 免疫反应性预计显示出运动-剂量关系，其中预计在较低分子量范围内反应最大。 还预计运动剂量与肌管增殖存在关系。