CREATINE SUPPLEMENT ON BODY COMPOSITION, MUSCLE PERFORMANCE AND MORPHOLOGY

肌酸补充剂对身体成分、肌肉性能和形态的影响

• 批准号: 6123201
• 负责人: WILLIAM KRAEMER
• 金额: $ 3.26万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123201
• 关键词: body composition; body physical characteristic; body water; body weight; clinical research; creatine; dietary supplements; exercise; hormone regulation /control mechanism; human subject; male; muscle function; muscle strength; nutrition related tag; striated muscles

The primary purpose of this investigation is to examine the acute and chronic effects of creatine supplementation in conjunction with resistance exercise training on muscle creatine loading, physical performance body composition and muscle morphology in men. This study will directly quantify creatine concentration in muscle before, immediately following an acute creatine loading regimen, and following a 12 week maintenance phase of creatine supplementation combined with a high intensity resistence training program. Furthermore, several aspects of performance including muscular strength, endurance, and power will be assessed following both short-term (acute loading) and long-term (Maintenance) creatine supplementation. Another controversial area associated with creatine supplementation is the impact on body weight and body composition. Most creatine studies have shown that 5-6 days of creatine loading leads to an increase in body weight. It is unknown whether the increase in body weight is due to lean body mass, total body water, or a combination of both. Given the short timne period it is expected that the increase in body weight is due to an increase in intracellular water in the body since the accretion of protein in cells generally occurs over a longer time frame. However, this issue requires further investigation. Similarly, the data regarding the effect of creatine supplementation on acute and chonic changes in lean body mass and body water retention is lacking. In summary, the information from this study will allow us to evaluate how individuals differ in their ability to acutely increase and maintain elevated levels of muscle creatine stores and how this relates to muscle morphology, body composition, hormonal concentrations and physical performance.

本研究的主要目的是研究肌酸补充结合抗阻运动训练对男性肌肉肌酸负荷、体能表现、身体组成和肌肉形态的急性和慢性影响。这项研究将直接量化肌肉中的肌酸浓度，在急性肌酸负荷方案之前，紧接着，在12周的肌酸补充维持阶段结合高强度阻力训练计划之后。此外，在短期（急性负荷）和长期（维持）补充肌酸后，将评估几个方面的表现，包括肌肉力量、耐力和力量。另一个与补充肌酸有关的争议领域是对体重和身体成分的影响。大多数肌酸研究表明，5-6天的肌酸负荷会导致体重增加。目前尚不清楚体重的增加是由于瘦体重、总体内水分还是两者兼而有之。鉴于时间较短，预计体重的增加是由于体内细胞内水分的增加，因为细胞内蛋白质的增加通常发生在较长的时间框架内。然而，这个问题需要进一步调查。同样，关于补充肌酸对瘦体重和体内水潴留的急性和慢性变化的影响的数据也缺乏。总之，这项研究的信息将使我们能够评估个体在急剧增加和维持高水平肌肉肌酸储存能力方面的差异，以及这与肌肉形态、身体成分、激素浓度和身体表现之间的关系。