CREATINE SUPPLEMENT ON BODY COMPOSITION, MUSCLE PERFORMANCE AND MORPHOLOGY

肌酸补充剂对身体成分、肌肉性能和形态的影响

• 批准号: 6283083
• 负责人: WILLIAM KRAEMER
• 金额: $ 2.16万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6283083
• 关键词: body composition; body physical characteristic; body water; body weight; clinical research; creatine; dietary supplements; exercise; hormone regulation /control mechanism; human subject; male; muscle function; muscle strength; nutrition related tag; striated muscles

The primary purpose of this investigation is to examine the acute and chronic effects of creatine supplementation in conjunction with resistance exercise training on muscle creatine loading, physical performance body composition and muscle morphology in men. This study will directly quantify creatine concentration in muscle before, immediately following an acute creatine loading regimen, and following a 12 week maintenance phase of creatine supplementation combined with a high intensity resistence training program. Furthermore, several aspects of performance including muscular strength, endurance, and power will be assessed following both short-term (acute loading) and long-term (Maintenance) creatine supplementation. Another controversial area associated with creatine supplementation is the impact on body weight and body composition. Most creatine studies have shown that 5-6 days of creatine loading leads to an increase in body weight. It is unknown whether the increase in body weight is due to lean body mass, total body water, or a combination of both. Given the short timne period it is expected that the increase in body weight is due to an increase in intracellular water in the body since the accretion of protein in cells generally occurs over a longer time frame. However, this issue requires further investigation. Similarly, the data regarding the effect of creatine supplementation on acute and chonic changes in lean body mass and body water retention is lacking. In summary, the information from this study will allow us to evaluate how individuals differ in their ability to acutely increase and maintain elevated levels of muscle creatine stores and how this relates to muscle morphology, body composition, hormonal concentrations and physical performance.

这项调查的主要目的是检查急性和 肌酸补充的慢性影响 肌肉肌酸负荷的阻力运动训练，身体 表现男性的身体成分和肌肉形态。这项研究 之前将直接量化肌肉中的肌酸浓度， 急性肌酸负荷方案后立即进行，并随后 肌酸补充的 12 周维持阶段结合 高强度阻力训练计划。此外，几个 表现方面，包括肌肉力量、耐力和爆发力 将根据短期（急性负荷）和长期进行评估 （维持）补充肌酸。另一个有争议的领域 与肌酸补充相关的是对体重的影响 和身体成分。大多数肌酸研究表明 5-6 天 肌酸负荷导致体重增加。未知 体重增加是否是由于去脂体重、全身 水，或两者的组合。鉴于时间较短 预计体重增加是由于 由于蛋白质的积累，体内细胞内的水 细胞通常会在较长的时间内发生。然而，这个问题 需要进一步调查。同样，有关数据 补充肌酸对瘦肉率急性和慢性变化的影响 体重和体内水分保留不足。综上所述， 这项研究的信息将使我们能够评估个人如何 它们急剧增加和维持高水平的能力不同 肌肉肌酸储存的情况及其与肌肉形态的关系， 身体成分、荷尔蒙浓度和身体表现。