CORE--CLINICAL

随着科学的急剧扩张和方法论的日益复杂， 阿尔茨海默病（AD）研究，对临床核心的需求， 明确定义的AD患者队列和年龄匹配的对照组， 变得更加复杂。 适合于一种类型的受试者队列 研究（如临床治疗结果试验）通常不 适用于其他类型的研究（例如，病例对照 流行病学研究或遗传连锁分析）以及其他类型 培训临床医生以管理多个 在AD过程中表现出的临床问题。 满足这些 多种需求，临床核心已经发展，并将继续 提供AD患者和正常健康对照的多个队列 适合支持学科招聘需求的广泛学科 AD的研究和临床培训范围。 固有队列将 继续纳入可能的AD和非痴呆老年对照 最大限度地适合参与临床研究， 最终尸检的可能性。 基因组包括 随访参与连锁的家族性AD患者 分析和其他遗传学研究。 AD和正常对照队列 与临床核心无关，但与临床核心密切相关， 用于流行病学研究或临床培训， 将继续得到培养。 此外，身患绝症的非痴呆患者 招募老年人并确定其特点， 捐献对照脑组织 通过这些队列，受试者 提供以满足ADRC调查人员的研究需求，其他 适当的调查人员在更广泛的华盛顿大学的研究 社区和其他机构的调查人员。

With the dramatic expansion and increased methodologic sophistication in Alzheimer's disease (AD) research, demands on the Clinical Core for clearly defined cohorts of persons with AD and age-matched controls have become more complex. A cohort of subjects appropriate for one type of investigation (such as a clinical treatment outcome trial) is often not appropriate for other types of studies (for example, a case-control epidemiologic study or a genetic linkage analysis) and still other types of cohorts are needed for training clinicians to manage the multiple clinical problems expressed during the course of AD. To meet these multiple demands, the Clinical Core has developed and will continue to provide multiple cohorts of AD patients and normal healthy control subjects suitable for supporting the subject recruitment needs of a broad range of research and clinical training in AD. The intrinsic cohort will continue to include probable AD and nondemented older controls selected for maximum appropriateness for participation in clinical studies and likelihood of obtaining eventual autopsy. The genetic cohort includes patients with familial AD who are followed for participation in linkage analysis and other genetic studies. AD and normal control cohorts extrinsic to but closely linked with the Clinical Core who are appropriate for epidemiologic studies or for clinical training have been developed and will continue to be fostered. In addition, terminally ill nondemented older persons are recruited and characterized to serve as volunteers for donation of control brain tissue. Through these cohorts, subjects are provided to meet the research needs of ADRC investigators, other appropriate investigators in the broader University of Washington research community, and investigators at other institutions.