CORE--CLINICAL

随着业务的戏剧性扩展和方法的复杂性 阿尔茨海默病(AD)研究，对临床核心的要求 明确定义的AD患者队列和年龄匹配的对照组 变得更加复杂。适合于一种类型的研究对象的队列 调查(如临床治疗结果试验)通常不是 适用于其他类型的研究(例如，病例对照 流行病学研究或遗传连锁分析)和其他类型 需要对临床医生进行培训以管理多个 在AD病程中表现出的临床问题。为了满足这些要求 多重需求，临床核心已经并将继续发展 提供多个AD患者队列和正常健康对照 适合学科配套的学科招生需求广泛 AD的研究和临床培训的范围。内在的队列将 继续包括选定的可能的AD和非痴呆的较旧控件 最大限度地适当地参与临床研究和 最终进行尸检的可能性。基因队列包括 家族性阿尔茨海默病患者参与连锁调查 分析和其他遗传研究。AD和正常对照队列 临床核心的外在但与临床核心密切相关的人 已开发出用于流行病学研究或临床培训的 将继续被培育。此外，绝症非痴呆症 老年人被招募并被描述为志愿人员 捐献对照脑组织。通过这些队列，受试者是 为满足ADRC调查人员的研究需要而提供，其他 华盛顿大学更广泛的研究中的适当调查人员 社区，以及其他机构的调查人员。

With the dramatic expansion and increased methodologic sophistication in Alzheimer's disease (AD) research, demands on the Clinical Core for clearly defined cohorts of persons with AD and age-matched controls have become more complex. A cohort of subjects appropriate for one type of investigation (such as a clinical treatment outcome trial) is often not appropriate for other types of studies (for example, a case-control epidemiologic study or a genetic linkage analysis) and still other types of cohorts are needed for training clinicians to manage the multiple clinical problems expressed during the course of AD. To meet these multiple demands, the Clinical Core has developed and will continue to provide multiple cohorts of AD patients and normal healthy control subjects suitable for supporting the subject recruitment needs of a broad range of research and clinical training in AD. The intrinsic cohort will continue to include probable AD and nondemented older controls selected for maximum appropriateness for participation in clinical studies and likelihood of obtaining eventual autopsy. The genetic cohort includes patients with familial AD who are followed for participation in linkage analysis and other genetic studies. AD and normal control cohorts extrinsic to but closely linked with the Clinical Core who are appropriate for epidemiologic studies or for clinical training have been developed and will continue to be fostered. In addition, terminally ill nondemented older persons are recruited and characterized to serve as volunteers for donation of control brain tissue. Through these cohorts, subjects are provided to meet the research needs of ADRC investigators, other appropriate investigators in the broader University of Washington research community, and investigators at other institutions.