NEUROBEHAVIOR, NEUROENDOCRINOLOGY, AND GENETICS OF AD

AD 的神经行为、神经内分泌学和遗传学

• 批准号: 6168603
• 负责人: MURRAY A RASKIND
• 金额: $ 22.85万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-15 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6168603
• 关键词: NEUROBEHAVIOR; NEUROENDOCRINOLOGY; GENETICS; AD

The proposed research training program will provide post-doctoral training in clinical research regarding the neurobehavior, neuroendocrinology, and neurogenetics of Alzheimer's Disease (AD) and related dementias. In particular, the program will focus on training clinical researchers capable of translating critical findings from basic science into hypotheses regarding the etiology, pathophysiology, and treatment of AD. Furthermore, clinical researchers will receive specialized training in two areas of study, neuroendocrinology and neurogenetics, that hold promise for increasing our understanding of the pathogenesis of AD and for developing new therapeutic approaches. Recent advances have underscored the importance of genetic factors such as amyloid precursor protein and presenilin mutations, and apolipoprotein epsilon genotype. Neuroendocrine factors such as estrogenic, glucoregulatory, and glucocorticoid status may also play an important pathogenetic role in modulating AD susceptibility genes, and thereby affect the neuropsychologic expression of AD. Clinical investigators capable of bridging the fields of neurogenetics, neuropsychology, and neuroendocrinology will be needed to disentangle and define these potentially critical interactions. The program will take place in the rich and interactive research environment of the University of Washington and the Veterans Affairs Puget Sound Health Care System, where a critical mass of faculty conduct both basic science and clinical research in the neuroendocrinology and neurogenetics of AD. The Alzheimer's Disease Research Center at the University of Washington will also serve as a resource for faculty and trainees. Given the interdisciplinary focus of the program, both Ph.D. and M.D. fellows will be included. As a new program, the number of slots has been restricted to two M.D. fellows and three Ph.D. post-doctoral fellows. M.D. fellowship candidates will have completed residency training in psychiatry or neurology, whereas Ph.D. fellowship candidates will have completed residency training in psychiatry or neurology, whereas Ph.D. fellowship candidates will have completed doctoral training in neuropsychology, geropsychology, cognitive aging, neuroendocrinology, or human genetics. All fellows will be required to completed a minimum of two years of fellowship, and additional years will be strongly encouraged. Although there is a long-standing commitment to aging training at our institution, our program is unique in its interdisciplinary nature and focus on clinical translational research in AD and related conditions. As such, it will provide a much-needed approach to the training of clinical research scientists whose work will address these complex disorders.

拟议的研究培训计划将提供有关阿尔茨海默病(AD)和相关痴呆的神经行为、神经内分泌学和神经遗传学的临床研究的博士后培训。特别是，该计划将侧重于培训临床研究人员，他们能够将基础科学的关键发现转化为关于AD的病因、病理生理学和治疗的假说。此外，临床研究人员将接受神经内分泌学和神经遗传学这两个研究领域的专门培训，这两个领域有望增加我们对AD发病机制的了解，并开发新的治疗方法。最近的进展强调了遗传因素的重要性，如淀粉样前体蛋白和早老素突变，以及载脂蛋白epsilon基因。神经内分泌因素，如雌激素、糖调节和糖皮质激素状态，也可能在调节AD易感基因方面发挥重要的致病作用，从而影响AD的神经心理表达。需要能够连接神经遗传学、神经心理学和神经内分泌学领域的临床研究人员来理清和界定这些潜在的关键相互作用。该计划将在华盛顿大学和退伍军人事务部普吉特声音医疗保健系统丰富和互动的研究环境中进行，在那里，关键的教职员工在AD的神经内分泌学和神经遗传学方面进行基础科学和临床研究。华盛顿大学的阿尔茨海默氏症研究中心也将作为教职员工和实习生的资源。鉴于该项目的跨学科重点，博士和医学博士研究员都将被包括在内。作为一个新项目，名额限制为两名医学博士研究员和三名博士后研究员。医学博士研究生将完成精神病学或神经学的住院医师培训，而博士研究生将完成精神病学或神经病学的住院医师培训，而博士研究生将完成神经心理学、老年心理学、认知衰老、神经内分泌学或人类遗传学的博士培训。所有研究员将被要求至少完成两年的奖学金，并将强烈鼓励更多的年份。尽管我们机构长期以来一直致力于老龄培训，但我们的项目在跨学科性质上是独一无二的，专注于AD和相关疾病的临床翻译研究。因此，它将提供一种急需的方法来培训临床研究科学家，他们的工作将解决这些复杂的疾病。