CORE--TRANSGENIC

该核心的目标是：1. 一个服务设施， 利用源自基因组的DNA构建体来创建创始人 转基因和基因敲除小鼠， 与肥胖和营养研究有关的问题; 2. 协商 肥胖和营养研究人员关于一般方面， 转基因和基因敲除工作，使用组织特异性 启动子，转基因和基因敲除构建体的产生， 转基因小鼠的建立和监测 殖民地;和3. 培训生成 转基因和基因敲除DNA构建体。

The objectives of this core are to provide: 1. A service facility that wil utilize investigator-derived DNA constructs to create founder transgenic and gene knockout mice that can be used to address questions relevant to obesity and nutrition research; 2. Consultations to obesity and nutrition researchers regarding general aspects of transgenic and gene knockout work, the use of tissue-specific promoters, the generation of transgenic and gene knockout constructs, and the establishment and monitoring of genetically modified mouse colonies; and 3. Training in methods required for the generation of transgenic and gene knockout DNA constructs.