Nonhuman Primate Housing Infrastructure and Caging

非人类灵长类动物住房基础设施和笼舍

• 批准号: 8183117
• 负责人: Jeffrey S Flier
• 金额: $ 48.3万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2013-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8183117
• 关键词: ABL2 gene; Animal Housing; Animals; Biological; Biological Models; Biomedical Research; Blood; Breeding; Core Facility; Country; Extramural Activities; Funding; Goals; Housing; Institutes; Laboratories; Macaca mulatta; Mission; New England; Primates; Recording of previous events; Request for Applications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Specific Pathogen Frees; System; Technology; Tissues; United States National Institutes of Health; base; design; environmental enrichment for laboratory animals; germ free condition; improved; medical schools; nonhuman primate; programs; square foot

DESCRIPTION (provided by applicant): The New England Primate Research Center (NEPRC) is one of eight National Primate Research Centers and has a long and productive history of biomedical research utilizing a variety of nonhuman primate-based model systems. The Center maintains both animal biolevel two (ABL2) and animal biolevel three (ABL3) core facilities and breeds specific pathogen free (SPF) rhesus macaques in support of this highly successful biomedical research program. As part of its mission, the NEPRC serves as a resource not only to core staff scientists located at the Center but also to scientists from across the country. There are currently 53 core and collaborative scientists with PHS-funded independent research grants that are assigned and house animals in the NEPRC facilities. These investigators represent 19 different nonprofit academic research organizations and receive funding from 13 categorical institutes within the NIH extramural system. In 2009, an additional 499 investigators benefited from the NEPRC facilities through other collaborative studies or access to blood, tissues or other biological resources. Harvard Medical School (HMS) recognizes this national resource mission and has supported the NEPRC through a number of major initiatives designed to improve and expand primate-related housing and laboratory infrastructure. Despite these improvements, the facilities are inadequate to support the current demand for animals and such specialized resources. This application requests funds to purchase a cage washer and caging to outfit a 18,700 gross square foot (gsf) primate housing facility currently under construction. The project makes extensive use of green technology to reduce ongoing utility and operating expenses and architectural features to enhance environmental enrichment of nonhuman primates. The overall goal of this proposal is to expand primate experimental housing and improve existing infrastructure in order to support a diverse biomedical research program. The project will directly benefit the national resource mission of the NEPRC and promote the availability and efficient utilization of resources by investigators conducting NIH-funded biomedical research.

描述（由申请人提供）：新英格兰灵长类动物研究中心（NEPRC）是八个国家灵长类动物研究中心之一，使用各种非人类灵长类动物的模型系统具有悠久而有效的生物医学研究历史。该中心同时维持动物生物层二（ABL2）和动物生物层三（ABL3）核心设施，并培养特定的无病原体（SPF）恒河猕猴，以支持这一非常成功的生物医学研究计划。作为其任务的一部分，NEPRC不仅是位于中心的核心员工科学家，而且还可以作为来自全国各地的科学家的资源。目前，有53位核心和合作科学家，在NEPRC设施中分配了PHS资助的独立研究补助金。这些研究人员代表19个不同的非营利学术研究组织，并从NIH壁外系统中的13个分类机构获得资金。 2009年，另外499名调查人员通过其他协作研究或获得血液，组织或其他生物资源的机会从NEPRC设施中受益。哈佛医学院（HMS）认可了这项国家资源任务，并通过许多旨在改善和扩展与灵长类动物相关的住房和实验室基础设施的主要举措来支持NEPRC。尽管有这些改进，但设施不足以支持当前对动物的需求和这种专业资源。该申请要求资金购买笼子洗衣机和笼子，以配备目前正在建设的18,700平方英尺（GSF）的灵长类设施。该项目广泛利用绿色技术来减少持续的公用事业，运营费用以及建筑特征，以增强非人类灵长类动物的环境丰富。该提案的总体目标是扩大灵长类动物的实验住房并改善现有的基础设施，以支持多样化的生物医学研究计划。该项目将直接受益于NEPRC的国家资源使命，并通过进行NIH资助的生物医学研究的研究人员促进资源的可用性和有效利用。